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首页> 外文期刊>Journal of Applied Polymer Science >Thermo- and pH- responsive copolymers: Poly(N-isopropylacrylamide-co-IAM) copolymers
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Thermo- and pH- responsive copolymers: Poly(N-isopropylacrylamide-co-IAM) copolymers

机译：对温度和pH敏感的共聚物：聚（N-异丙基丙烯酰胺-co-IAM）共聚物

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摘要

Poly(N-isopropylacrylamide) (NIPAAm) is well known as a smart material with good thermal sensitivity and favorable biocompatibility. A series of new smart hydrogels, NIPAAm copolymerized with IAM (itaconamic acid; 4-amino-2-methylene-4-oxobutanoic acid), were synthesized through radical solution polymerization in this work. Poly(NIPAAm-co-IAM) can respond to the changes of temperature as well as pH value. Such a characteristic is due to the fact that IAM contains not only a hydrophilic acrylic acid moiety but also an acrylamide moiety to be thermal and pH sensitive. The experimental results show that the lower critical solution temperature (LCST) of the copolymer increases as the molar fraction of IAM increases. Moreover, based on the current experimental data, 3 wt % of Poly(NIPAAm-co-IAM) aqueous solution in this study exhibits a phase transition temperature (37.8 degrees C) close to the human body temperature in the buffer solution of pH 7 possibly to be useful in drug delivery. (C) 2015 Wiley Periodicals, Inc.
机译：聚（N-异丙基丙烯酰胺）（NIPAAm）是众所周知的智能材料，具有良好的热敏性和良好的生物相容性。通过自由基溶液聚合，合成了一系列新型智能水凝胶，与IAM（衣康康酸; 4-氨基-2-亚甲基-4-氧代丁酸）共聚的NIPAAm。聚（NIPAAm-co-IAM）可以响应温度和pH值的变化。这样的特性是由于IAM不仅包含亲水性丙烯酸部分而且还包含对热和pH敏感的丙烯酰胺部分这一事实。实验结果表明，随着IAM摩尔分数的增加，共聚物的较低临界溶液温度（LCST）升​​高。此外，根据目前的实验数据，本研究中3 wt％的Poly（NIPAAm-co-IAM）水溶液在pH值为7的缓冲溶液中显示出接近人体温度的相变温度（37.8摄氏度）。在药物输送中很有用。 （C）2015年Wiley Periodicals，Inc.

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