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首页> 外文期刊>Journal of Applied Polymer Science >5-Fluorouracil encapsulated magnetic nanohydrogels for drug-delivery applications
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5-Fluorouracil encapsulated magnetic nanohydrogels for drug-delivery applications

机译：5-氟尿嘧啶封装的磁性纳米水凝胶，用于药物输送应用

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For the first time, green-tea (GT)-based magnetic nanohydrogels were developed for drug-delivery purposes. The hydrogel matrices were fabricated via the in situ polymerization of acrylamide with GT molecules. Magnetic nanoparticles were synthesized by the reduction of the 1:2 molar ratio mixture of ferrous sulfate heptahydrate and ferric chloride hexahydrate with an ammonia solution. A chemotherapeutic drug, 5-fluorouracil, was chosen as a model drug, and its releasing profiles in the presence and absence of the external magnetic field were evaluated at a pH of 7.4. We observed that in the presence of the applied magnetic field, these magnetic nanohydrogels released 2.86% more drug than in the absence of a magnetic field. The magnetic nanohydrogels were characterized by X-ray diffraction, Fourier transform infrared spectroscopy, scanning electron microscopy, vibrating sample magnetometry, and transmission electron microscopy. (c) 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 43921.
机译：第一次，基于绿茶（GT）的磁性纳米水凝胶被开发用于药物递送目的。通过丙烯酰胺与GT分子的原位聚合制备水凝胶基质。通过用氨溶液还原七水合硫酸亚铁和六水合氯化铁的1：2摩尔比混合物来合成磁性纳米粒子。选择化学疗法药物5-氟尿嘧啶作为模型药物，并在pH值为7.4的条件下评估在有无外磁场下的释放曲线。我们观察到，在存在磁场的情况下，与没有磁场的情况相比，这些磁性纳米水凝胶释放的药物多出2.86％。磁性纳米水凝胶通过X射线衍射，傅立叶变换红外光谱，扫描电子显微镜，振动样品磁强度和透射电子显微镜进行了表征。 （c）2016 Wiley Periodicals，Inc. J. Appl。 Polym。科学2016，133，43921。

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