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首页> 外文期刊>Journal of Applied Polymer Science >Hybrid biomimetic electrospun fibrous mats derived from poly(epsilon-caprolactone) and silk fibroin protein for wound dressing application
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Hybrid biomimetic electrospun fibrous mats derived from poly(epsilon-caprolactone) and silk fibroin protein for wound dressing application

机译：源自聚ε-己内酯和丝素蛋白的混合仿生电纺纤维毡，用于伤口包扎

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摘要

To achieve excellent biofunctionality of Bombyx mori silk fibroin (SF), we explored a novel hybridization method to combine the unique properties of SF with poly(epsilon-caprolactone) (PCL) electrospun fibers. The hybrid electrospun fibers demonstrate excellent hydrophilicity and biocompatibility that are important to tissue engineering applications. The biomimetic fibrous structure was fabricated by conventional electrospinning of PCL. The individual surfaces of PCL electrospun fibers were coated with silk fibroin protein using a lyophilization technique. The SF coating layers were durable which were further developed by surface modification with fibronectin to improve their biological function. The hybrid electrospun fibers show excellent support for normal human dermal fibroblast (NHDF) cells adhesion and proliferation than neat PCL fibers, while the surface-modified hybrid electrospun fibers show significantly enhanced proliferation of NHDF cells on their surface. This study indicates the new opportunity of fabrication technique that can construct a biomimetic fibrous structure while the original function as a biomaterial remained existing. (c) 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 41653.
机译：为了实现家蚕丝素蛋白（SF）的出色生物功能，我们探索了一种新颖的杂交方法，将SF的独特特性与聚（ε-己内酯）（PCL）电纺丝结合起来。混合电纺纤维具有出色的亲水性和生物相容性，这对组织工程应用很重要。仿生纤维结构是通过PCL的常规电纺丝制成的。使用冻干技术，将PCL电纺纤维的各个表面涂上丝素蛋白蛋白。 SF涂层坚固耐用，可通过纤连蛋白表面改性进一步开发以改善其生物学功能。与纯PCL纤维相比，杂合电纺纤维对正常人真皮成纤维细胞（NHDF）细胞的粘附和增殖表现出出色的支持，而表面改性的杂合电纺纤维在表面上显着增强了NHDF细胞的增殖。这项研究表明了制造技术的新机会，该技术可以构建仿生纤维结构，同时保留原有的生物材料功能。 （c）2014 Wiley Periodicals，Inc. J. Appl。 Polym。科学2015，132，41653。

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