• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Applied Polymer Science >Influence of structure on release profile of acyclovir loaded polyurethane nanofibers: Monolithic and core/shell structures
【24h】

Influence of structure on release profile of acyclovir loaded polyurethane nanofibers: Monolithic and core/shell structures

机译：结构对无环鸟苷负载的聚氨酯纳米纤维释放特性的影响：整体结构和核/壳结构

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

In this study, monolithic and core/shell polyurethane (PU) nanofibers were fabricated by single and coaxial electrospinning techniques, respectively. An antivirus drug, Acyclovir (ACY), was loaded on PU nanofibers. The physical condition and interaction of the loaded ACY within these nanofibers were studied by FTIR, XRD, DSC, SEM, and TEM. In vitro tests exhibited an obvious difference in the release pattern between monolithic and core/shell nanofibers and burst release in monolithic nanofibers could be controlled by core/shell structure. Release profile was found to follow Korsmeyere-Peppas model with Fickian diffusion mechanism. Our study demonstrated that the ACY-loaded core/shell nanofibers might serve as a device for drug delivery systems. (C) 2016 Wiley Periodicals, Inc.
机译：在这项研究中，单片和核/壳聚氨酯（PU）纳米纤维分别通过单根和同轴电纺丝技术制造。一种抗病毒药物阿昔洛韦（ACY）被装载到PU纳米纤维上。通过FTIR，XRD，DSC，SEM和TEM研究了这些纳米纤维中负载的ACY的物理条件和相互作用。体外测试显示，整体式和核/壳纳米纤维之间的释放模式存在明显差异，并且整体式纳米纤维的破裂释放可以通过核/壳结构来控制。发现释放曲线遵循具有Fickian扩散机制的Korsmeyere-Peppas模型。我们的研究表明，载有ACY的核/壳纳米纤维可作为药物输送系统的装置。 （C）2016威利期刊公司

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号