• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Applied Polymer Science >Effect of ionic liquids on the structural, thermal, and in vitro degradation properties of poly(epsilon-caprolactone) synthesized in the presence of Candida antarctica lipase B
【24h】

Effect of ionic liquids on the structural, thermal, and in vitro degradation properties of poly(epsilon-caprolactone) synthesized in the presence of Candida antarctica lipase B

机译：离子液体对在南极假丝酵母脂肪酶B存在下合成的聚（ε-己内酯）的结构，热和体外降解特性的影响

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The study provides detailed information on the differences in the structural, thermal and degradation properties of poly(e-caprolactone) synthesized in two different ionic liquids, 1-butyl-3-methylimidazolium hexafluorophosphate [bmim][PF6] and 1-butyl-3-methylimidazolium bis(trifluoromethylsulfonyl) imide [bmim][NTf2], regarding its further usage in the pharmaceutical field. The polymer structure confirms the presence of both linear polymer chains with end-functional hydroxyl groups allowing covalent coupling of the therapeutic agents, and cyclic macromolecules, both affecting the degree of crystallinity of polymer. The highest macrocyclic content (64%) after 7 days of polymerization at 80 degrees C was observed for [bmim][NTf2]. For [bmim][PF6], the macrocyclic content value was not dependent on the reaction time and remained at a similar level (10-14% at 80 degrees C). The results of degradation test revealed that hydrolytic degradation of ester bonds is more pronounced for PCLs synthesized in [bmim][NTf2], due to their lower degree of crystallinity compared with PCLs obtained in [bmim][PF6]. A high purity, low polydispersity index of the obtained polymers and high yield of the process (ca., 90%) indicate that ionic liquids seem to be promising solvents for the synthesis of biomedical polymers. (C) 2016 Wiley Periodicals, Inc.
机译：这项研究提供了有关在两种不同的离子液体（六丁基磷酸1-丁基-3-甲基咪唑鎓[bmim] [PF6]和1-丁基-3）中合成的聚（ε-己内酯）的结构，热和降解特性差异的详细信息。 -甲基咪唑双（三氟甲基磺酰基）酰亚胺[bmim] [NTf2]，有关其在制药领域的进一步用途。聚合物结构证实了两个带有末端官能羟基的线性聚合物链的存在，从而允许治疗剂与环状大分子共价偶联，两者均影响聚合物的结晶度。对于[bmim] [NTf2]，在80℃下聚合7天后观察到最高的大环含量（64％）。对于[bmim] [PF6]，大环含量值不依赖于反应时间，而是保持在相似的水平（在80摄氏度下为10-14％）。降解测试的结果表明，与[bmim] [PF6]中获得的PCL相比，在[bmim] [NTf2]中合成的PCL的酯键水解降解更为明显。所得聚合物的高纯度，低多分散性指数和高产率的方法（约90％）表明，离子液体似乎是合成生物医学聚合物的有前途的溶剂。 （C）2016威利期刊公司

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号