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首页> 外文期刊>Journal of Applied Polymer Science >Epoxy resin-based ultrafine dry powder coatings for implants
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Epoxy resin-based ultrafine dry powder coatings for implants

机译：用于植入物的环氧树脂基超细干粉涂料

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Ultrafine dry powder coating technology creates biocompatible polymeric coatings for implants. Nanoparticles (nTiO(2)) modify flow to prevent agglomeration and create homogenous coatings. Since polyester-based coatings require the potentially harmful 1,3,5-triglycidyl isocyanurate (TGIC) curing agent, this study's objective was to develop alternative TGIC-free formulations. Epoxy and epoxy/polyester (1:1) hybrid mixtures were enriched with CaO (5% w/w) and nTiO(2) (0.5% w/w), as functional additives and flow modifiers, respectively. Epoxy-TiO2 and Hybrid-TiO2 mixtures were prepared with micron-sized TiO2 (25% w/w) to enhance biocompatibility. Polymer chips and additives were combined in a high-shear mixer and passed through a sieve (35 mu m) to yield ultrafine particles that were sprayed (20kV) onto metal sheets and cured (200 degrees C). Particle size analyses showed that all formulations were ultrafine (D 0.5<35 mu m), and epoxy/polyester/TiO2 mixtures were the smallest (D 0.5=16.34 mu m). Angles of repose, avalanche and resting indicated reduced flowability when epoxy was enriched with TiO2 and/or polyester, although all formulae were highly flowable. Elemental mapping of coatings showed a predominance of carbon (C) and oxygen (O) from resin polymer, and elevated titanium (Ti) in the TiO2 enriched surfaces. However, calcium (Ca) clusters were higher on the epoxy/polyester Hybrid coatings. Optical microscopy showed human mesenchymal cells (ATCC CRL-1486) attached and spread out, and Alizarin Red staining showed mineral deposits in 2-4 week cultures, particularly on epoxy/polyester/TiO2 Hybrid surfaces. These epoxy resin-based formulations were effective TGIC-free substitutes for ultrafine dry powder coatings on implants. (c) 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 43960.
机译：超细干粉涂层技术可为植入物创造生物相容性聚合物涂层。纳米粒子（nTiO（2））修改流量以防止团聚并创建均匀的涂层。由于基于聚酯的涂料需要潜在有害的1,3,5-三缩水甘油基异氰脲酸酯（TGIC）固化剂，因此本研究的目的是开发替代无TGIC的配方。环氧和环氧/聚酯（1：1）混合混合物分别富含CaO（5％w / w）和nTiO（2）（0.5％w / w），分别作为功能性添加剂和流动改性剂。用微米级的TiO2（25％w / w）制备了环氧TiO2和杂化TiO2混合物，以增强生物相容性。将聚合物碎片和添加剂在高剪切混合器中合并，并通过筛子（35μm），得到超细颗粒，将其喷涂（20kV）到金属板上并固化（200摄氏度）。粒度分析表明，所有配方均超细（D 0.5 <35μm），环氧/聚酯/ TiO2混合物最小（D 0.5 = 16.34μm）。当环氧树脂富含TiO2和/或聚酯时，休止角，雪崩角和静止角表明流动性降低，尽管所有配方的流动性都很高。涂层的元素图谱表明，树脂聚合物中的碳（C）和氧（O）占优势，而TiO2富集的表面中钛（Ti）升高。但是，环氧/聚酯杂化涂料中的钙（Ca）簇较高。光学显微镜显示人间充质细胞（ATCC CRL-1486）附着并扩散，茜素红染色显示2-4周的培养物中有矿物质沉积，特别是在环氧/聚酯/ TiO2杂化表面上。这些基于环氧树脂的配方是植入物上超细干粉涂料的有效无TGIC替代品。 （c）2016 Wiley Periodicals，Inc. J. Appl。 Polym。科学2016，133，43960。

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