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首页> 外文期刊>Journal of Applied Polymer Science >Near-infrared-active and pH-responsive fluorescent polymer-integrated hybrid graphene oxide nanoparticles for the detection and treatment of cancer
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Near-infrared-active and pH-responsive fluorescent polymer-integrated hybrid graphene oxide nanoparticles for the detection and treatment of cancer

机译：近红外活性和pH响应荧光聚合物集成的混合氧化石墨烯纳米颗粒用于癌症的检测和治疗

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Hybrid nanoparticles for theragnosis have great potentiality to bring desire functionalities in one integrated system. The development of bioimaging guided photothermal therapy (PTT) is pivotal in optimizing cytotoxic cancer therapy. We report nearinfrared (NIR)-active and pH-responsive fluorescent, catechol-conjugated, reduced graphene oxide (rGO)-anchored hybrid nanoparticles that can sharply increase the photothermal heat in response to NIR exposure and exhibit pH-dependent fluorescence emission for the detection of tumor areas without causing cell toxicity. The optoelectronic absorption property of poly(3,4-ethylenedioxythiophene) [PEDOT]: dopamine-conjugated poly(4-styrenesulfonate-co-maleic acid) [D-PSM] and 3',4'-dihydroxyacetophenone/boron-dipyrromethene [CCDP/BODIPY]-quaternized polyethylene glycol grafted poly(dimethylaminoethyl methacrylate) (C/B-PgP) present in this hybrid nanoparticles resulted in efficient photothermal conversion with pH-tunable fluorescence that exerted sufficient photothermal cytotoxicity to cancer cells. The in vitro cellular uptake was measured by confocal laser scanning microscopy, allowing the therapeutic efficiency and bioimaging effects to be explored. We expect that the broad optical absorption property of PEDOT:D-PSM with BODIPY-conjugated polymers on rGO sheets would get tremendous attraction in this enormous rising PTT with cancer detectable biomarker. (C) 2016 Wiley Periodicals, Inc.
机译：用于鼻甲的杂化纳米颗粒具有在一个集成系统中带来所需功能的巨大潜力。生物成像引导光热疗法（PTT）的发展对于优化细胞毒性癌症治疗至关重要。我们报告了近红外（NIR）活性和pH响应荧光，邻苯二酚共轭，还原氧化石墨烯（rGO）锚定的杂化纳米颗粒，这些纳米颗粒可以响应于NIR暴露而急剧增加光热，并显示出与pH有关的荧光发射不会引起细胞毒性的肿瘤区域。聚（3,4-乙撑二氧噻吩）[PEDOT]的光电子吸收特性：多巴胺共轭聚（4-苯乙烯磺酸盐-顺丁烯二酸）[D-PSM]和3'，4'-二羟基苯乙酮/硼-二吡咯甲烯[CCDP]存在于该杂化纳米颗粒中的/ [BODIPY]-季铵化的聚乙二醇接枝的聚甲基丙烯酸二甲基氨基乙基酯（C / B-PgP）导致有效的光热转化，并带有可调节pH的荧光，从而对癌细胞产生了足够的光热细胞毒性。通过共聚焦激光扫描显微镜测量体外细胞摄取，从而探索治疗效率和生物成像效果。我们预计，在这种具有癌症可检测生物标志物的巨大PTT上升中，PEDOT：D-PSM与BODIPY共轭聚合物在rGO片材上的广泛的光吸收特性将获得巨大的吸引力。 （C）2016威利期刊公司

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