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首页> 外文期刊>Journal of Applied Polymer Science >Electrospun poly(vinyl alcohol) composite nanofibers with halloysite nanotubes for the sustained release of sodium D-pantothenate
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Electrospun poly(vinyl alcohol) composite nanofibers with halloysite nanotubes for the sustained release of sodium D-pantothenate

机译：具有埃洛石纳米管的静电纺丝聚乙烯醇复合纳米纤维，用于D-泛酸钠的持续释放

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Poly(vinyl alcohol) (PVA) nanofibers containing halloysite nanotubes (HNTs) loaded with sodium D-pantothenate (SDP) were successfully fabricated via simple blend-electrospinning. SDP was efficiently loaded into the innate HNT lumen with an SDP/HNT mass ratio of 1.5:1 via vacuum treatment. The SDP-loaded HNT-inclusion complex was evaluated with drug-loading efficiency testing, Fourier transform infrared (FTIR) spectroscopy, and X-ray diffraction. The morphologies of the nanofibers were observed by scanning electron microscopy, which revealed uniform and smooth surfaces of the nanofibers. The addition of HNTs to the composite nanofibers increased the viscosity of the polymer solution, and this suggested shorter fiber diameters. FTIR spectroscopy verified the good compatibility of the SDP and HNTs with PVA. Moreover, the swelling properties were found to quantitatively correlate with weight loss. In vitro drug-release testing revealed that the HNTs and crosslinking reaction most dramatically affected the sustained release of SDP from the PVA and SDP-loaded HNT complex. In the drug-release kinetics model, SDP release depended on the diffusion caused by the deformation of the polymer-based structures in the medium; it followed Fickian diffusion with acceptable coefficient of determination (r(2)) values between 0.88 and 0.94. Most importantly, the HNTs as natural biocontainers effectively modulated the release profile by loading the active compound in harmony with the electrospun nanofibers. (C) 2015 Wiley Periodicals, Inc.
机译：通过简单的共混静电纺丝法成功地制备了含有负载有D-泛酸钠（SDP）的埃洛石纳米管（HNT）的聚乙烯醇（PVA）纳米纤维。通过真空处理将SDP以1.5：1的SDP / HNT质量比有效地加载到先天HNT腔中。通过载药效率测试，傅立叶变换红外（FTIR）光谱和X射线衍射评估了SDP负载的HNT包含物复合物。通过扫描电子显微镜观察纳米纤维的形态，其揭示了纳米纤维的均匀且光滑的表面。向复合纳米纤维中添加HNT会增加聚合物溶液的粘度，这表明纤维直径更短。 FTIR光谱验证了SDP和HNT与PVA的良好兼容性。此外，发现膨胀特性与体重减轻在数量上相关。体外药物释放测试表明，HNT和交联反应对从PVA和SDP负载的HNT复合物中SDP的持续释放影响最大。在药物释放动力学模型中，SDP的释放取决于介质中聚合物基结构变形引起的扩散。它遵循Fickian扩散，其确定系数（r（2））值在0.88至0.94之间。最重要的是，作为天然生物容器的HNT通过负载活性化合物与电纺纳米纤维相协调，有效地调节了释放特性。 （C）2015年Wiley Periodicals，Inc.

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