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Trifunctional cross-linker trimethylol melamine enhancing adhesive force of PVA hydrogels

机译:三官能交联剂三羟甲基三聚氰胺提高了PVA水凝胶的粘合力

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摘要

Adhesive force is a critical feature in vitro for soft hydrogels as wound dressing. Here we employ trimethylol melamine as a tri-functional cross-linker to enhance the adhesive force of poly(vinyl alcohol) (PVA) hydrogels. First, trimethylol melamine was prepared using melamine and formaldehyde by a condensation reaction. Then PVA was cross-linked in an aqueous medium to form hydrogels by using trimethylol melamine as a cross-linker, It was found that trimethylol melamine cross-linked PVA hydrogels (TMCPVA) exhibited a good adhesion property with a low degree of cross-linking and no residue after the TMCPVA peeled from skins, indicating the TMCPVA were suitable for adhesive wound dressing. Moreover, their structures, morphology and adhesive forces were characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and texture analyzer (TA). The results indicated that TMCPVA would be promising wound dressing materials with biocompatible and well-adhesive properties. (C) 2016 Wiley Periodicals, Inc.
机译:对于软水凝胶而言,粘附力是体外重要的伤口敷料。在这里,我们采用三羟甲基三聚氰胺作为三官能交联剂,以增强聚乙烯醇(PVA)水凝胶的粘合力。首先,使用三聚氰胺和甲醛通过缩合反应制备三羟甲基三聚氰胺。然后,将三羟甲基三聚氰胺交联的PVA水凝胶(TMCPVA)在水性介质中交联以形成水凝胶,发现三羟甲基三聚氰胺交联的PVA水凝胶(TMCPVA)具有良好的粘合性,交联度低。并且TMCPVA从皮肤上剥离后没有残留,表明TMCPVA适合用于粘性伤口敷料。此外,通过傅立叶变换红外光谱(FTIR),扫描电子显微镜(SEM)和质构分析仪(TA)表征了它们的结构,形态和粘附力。结果表明,TMCPVA有望成为具有生物相容性和良好粘合性能的创口敷料。 (C)2016威利期刊公司

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