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Microwave-assisted synthesis of chitosan biguanidine hydrochloride and its antioxidant activity in vitro

机译：微波辅助壳聚糖双胍盐酸盐的合成及其体外抗氧化活性

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摘要

Chitosan biguanidine hydrochloride (CSGH) was synthesized by guanidinylation of chitosan hydrochloride (CSH) under microwave irradiation and characterized by Fourier transform infrared spectroscopy, gel permeation chromatography, and element analysis. The antioxidant activity of CSGH was evaluated by both chemical and cellular methods. The results showed that CSGH was better than CSH but slightly inferior to ascorbic acid (Vc) for scavenging 2,2-diphenyl-1-picryl-hydrazyl (DPPH) free radicals, and the DPPH center dot scavenging ability of CSGH was dose-dependent. However, cell experiments indicated CSGH had a superior repairing effect on oxidatively damaged cells. The intervention of CSGH could excellently recover the cell morphology, decrease the level of malondialdehyde, and enhance the activity of superoxide dismutase and glutathione peroxidase. CSGH could be a potential antioxidant reagent, and its antioxidant activity was reflected not only in scavenging the free radicals but also in regulating the oxidation/antioxidation balance of damaged cells. (c) 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 43570.
机译：壳聚糖双胍盐酸盐（CSH）在微波辐射下的胍基化反应合成了壳聚糖双胍盐酸盐（CSGH），并通过傅里叶变换红外光谱，凝胶渗透色谱和元素分析进行​​了表征。通过化学和细胞方法评估了CSGH的抗氧化活性。结果表明，CSGH在清除2,2-二苯基-1-吡啶基-肼基（DPPH）自由基方面优于CSH，但稍逊于抗坏血酸（Vc），CSGH的DPPH中心点清除能力与剂量有关。 。但是，细胞实验表明CSGH对氧化损伤的细胞具有优异的修复作用。 CSGH的干预可以很好地恢复细胞形态，降低丙二醛水平，并增强超氧化物歧化酶和谷胱甘肽过氧化物酶的活性。 CSGH可能是潜在的抗氧化剂，其抗氧化活性不仅体现在清除自由基，还体现在调节受损细胞的氧化/抗氧化平衡。 （c）2016 Wiley Periodicals，Inc. J. Appl。 Polym。科学2016，133，43570。

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