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首页> 外文期刊>Journal of Applied Polymer Science >Stimuli-responsive molecularly imprinted hybrid polymer gel as a potential system for controlled release
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Stimuli-responsive molecularly imprinted hybrid polymer gel as a potential system for controlled release

机译：刺激响应分子印迹杂化聚合物凝胶作为控释的潜在系统

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The purpose of this study is to develop a stimuli-responsive hybrid polymer gel system with an improved mechanical stability as a controlled drug delivery carrier that can undergo phase transition by the stimulation of ethanol-water mixture. For this aim, trimethoxysilane terminated poly(propylene glycol) by coupling of 3-isocyanatopropyl-triethoxysilane with the hydroxyl end groups of poly(propylene glycol) through urethane bonds was synthesized. Hybrid polymer gels prepared in the presence of tryptophan (Trp), as a model of drug, were characterized and gelation time of polymer network was obtained by monitoring the fluorescence emission of Trp in pre-gel solution. Swelling, solvent uptake and release kinetic of polymer gels were evaluated depending on time. The diffusional exponents (n) and diffusion constants (k) of each gel were calculated by using the swelling kinetic data. The effect of precursors as a monomer on Trp release profile was analyzed. (C) 2015 Wiley Periodicals, Inc.
机译：这项研究的目的是开发一种刺激响应性的杂化聚合物凝胶体系，该体系具有改善的机械稳定性，作为受控的药物输送载体，可以通过乙醇-水混合物的刺激发生相变。为了这个目的，通过使3-异氰酸根合丙基-三乙氧基硅烷通过氨基甲酸酯键与聚（丙二醇）的羟基端基偶联来合成三甲氧基硅烷封端的聚丙二醇。表征了在色氨酸（Trp）存在下制备的杂化聚合物凝胶（作为药物模型），并通过监测预凝胶溶液中Trp的荧光发射来获得聚合物网络的胶凝时间。根据时间评估聚合物凝胶的溶胀，溶剂吸收和释放动力学。使用溶胀动力学数据计算每种凝胶的扩散指数（n）和扩散常数（k）。分析了前体作为单体对Trp释放曲线的影响。 （C）2015威利期刊公司

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