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首页> 外文期刊>Journal of Alloys and Compounds: An Interdisciplinary Journal of Materials Science and Solid-state Chemistry and Physics >Nanoporous surface topography enhances bone cell differentiation on Ti-6Al-7Nb alloy in bone implant applications
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Nanoporous surface topography enhances bone cell differentiation on Ti-6Al-7Nb alloy in bone implant applications

机译：纳米多孔表面形貌可增强Ti-6Al-7Nb合金在骨植入应用中的骨细胞分化

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摘要

V-free Ti alloys are viewed as a promising alternative to biomedical Ti-Al-V alloys in bone implant applications. However, the biological response to these alloys depends heavily on the surface characteristics of the implant as well as on the choice of material. This study treated Ti-6Al-7Nb alloys with electrochemical anodization in an alkaline solution for the creation of a thin nanoporous layer (<100 nm in thickness) to improve bone cell differentiation. The resulting hydrophilic surface nanotopography resulted in anodized Ti-6Al-7Nb alloy with pores 10-100 nm. Compared to untreated alloys, the proposed surface treatment was shown to enhance the blood responses, alkaline phosphatase activity, mineralization, and expression of Runx2 transcription factor and various osteogenic markers, including the gene and protein expression of osteopontin, osteocalcin, bone sialoprotein, and type I collagen, from human bone marrow mesenchymal stem cells. The increased expression of osteogenic markers is expected to promote in vivo osseointegration on Ti-6Al-7Nb alloy in bone implant applications. This might be the first report on the enhancement of osteogenic gene and protein expressions on Ti-6Al-7Nb alloy through rapid formation of hydrophilic surface nanotopography. (C) 2015 Elsevier B.V. All rights reserved.
机译：在骨植入物应用中，无V的Ti合金被认为是生物医学Ti-Al-V合金的有前途的替代品。但是，对这些合金的生物反应在很大程度上取决于植入物的表面特性以及材料的选择。这项研究在碱性溶液中对Ti-6Al-7Nb合金进行了电化学阳极氧化处理，以形成薄的纳米多孔层（厚度<100 nm）来改善骨细胞的分化。所得的亲水性表面纳米形貌产生具有孔10-100nm的阳极氧化的Ti-6Al-7Nb合金。与未处理的合金相比，拟议的表面处理显示出增强的血液反应，碱性磷酸酶活性，矿化和Runx2转录因子及多种成骨标记物的表达，包括骨桥蛋白，骨钙蛋白，骨唾液蛋白和类型的基因和蛋白质表达。我的胶原蛋白，来自人骨髓间充质干细胞。预期成骨标记物表达的增加将促进Ti-6Al-7Nb合金在骨植入应用中的体内骨整合。这可能是关于通过快速形成亲水表面纳米形貌来增强Ti-6Al-7Nb合金上成骨基因和蛋白质表达的第一个报道。 （C）2015 Elsevier B.V.保留所有权利。

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