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Systems biology approaches in identifying the targets of natural compounds for cancer therapy.

机译：系统生物学方法用于鉴定天然化合物用于癌症治疗的靶标。

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摘要

Natural compounds have been known to exert inhibitory effects on the development and progression of human cancers. However, the targets of these naturally occurring agents are largely elusive. Recently, systems biology approaches based on high-throughput technologies such as DNA microarrays have begun to be utilized for investigating the targets of drugs including natural compounds. Therefore, in this review article, we will briefly introduce the several systems biology approaches, and will discuss the application of these new technologies for identifying the therapeutic targets of natural compounds for supporting their roles in the prevention and/or treatment of human cancers. Furthermore, identification of the novel targets will be useful for designing more effective and targeted therapeutic strategies for achieving better treatment outcome in patients diagnosed with cancers.
机译：已知天然化合物对人类癌症的发生和发展具有抑制作用。然而，这些天然存在的药剂的目标在很大程度上难以捉摸。最近，基于高通量技术（例如DNA微阵列）的系统生物学方法已开始用于研究包括天然化合物在内的药物靶标。因此，在这篇综述文章中，我们将简要介绍几种系统生物学方法，并将讨论这些新技术在鉴定天然化合物治疗靶点方面的应用，以支持其在人类癌症的预防和/或治疗中的作用。此外，新靶标的鉴定对于设计更有效和针对性的治疗策略将很有用，以在诊断为癌症的患者中获得更好的治疗结果。

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