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首页> 外文期刊>Journal of Clinical Oncology >Staging of ciliary body and choroidal melanomas based on anatomic extent.
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Staging of ciliary body and choroidal melanomas based on anatomic extent.

机译：睫状体和脉络膜黑色素瘤的分期基于解剖范围。

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PURPOSE To refine the anatomic classification and staging of ciliary body and choroidal melanomas in the TNM classification. PATIENTS AND METHODS Tumor largest basal diameter and thickness of 7,369 patients were analyzed based on registry data from five ocular oncology centers. T categories were derived empirically by dividing data into blocks representing 3- × 3-mm fractions. Blocks with similar survival were grouped together so that no T category comprised a large majority of tumors, and each was uniform in survival, using randomly drawn 60% building and 40% validation data sets. Presence of ciliary body involvement (CBI) and extraocular extension (EXE) was analyzed among 5,403 patients to define T subcategories. Stages were generated by iteratively combining subcategories with similar survival. Results Of the 7,369 tumors analyzed, 24% were classified as T1, 33% as T2, 31% as T3, and 12% as T4. Ten-year Kaplan-Meier survival estimates for the T categories were 89%, 77%, 58%, and 39%, respectively (P < .001). Survival of patients in four subcategories based on presence or absence of CBI and EXE differed significantly within each T category (P = .018 for T1; P < .001 for T2 to T4). EXE exceeding 5 mm in largest diameter carried a worse prognosis than smaller extensions (P < .001) and was assigned a separate subcategory. Ten-year Kaplan-Meier survival estimates for stages I, IIA to IIB, and IIIA to IIIC were 88%, 80%, 67%, 45%, 27%, 10%, respectively (P < .001). CONCLUSION This evidence-based anatomic classification provides a basis for staging ciliary body and choroidal melanomas in the seventh edition of the Cancer Staging Manual of the American Joint Committee on Cancer.
机译：目的在TNM分类中细化睫状体和脉络膜黑色素瘤的解剖学分类和分期。患者和方法根据来自五个眼肿瘤中心的注册数据，分析了7369名患者的肿瘤最大基底直径和厚度。通过将数据划分为代表3-×3-mm分数的块，根据经验得出T类。使用随机抽取的60％构建和40％验证数据集将具有相似生存期的块归为一组，以便没有T类占绝大多数肿瘤，并且每个生存期都一致。在5403例患者中分析了睫状体受累（CBI）和眼外延伸（EXE）的存在，以定义T亚类。通过迭代组合具有相似生存率的子类别来产生阶段。结果分析的7369例肿瘤中，有24％被归类为T1，33％被归类为T2，31％被归类为T3，12％被归类为T4。 T类的十年Kaplan-Meier生存估计分别为89％，77％，58％和39％（P <.001）。在每个T类中，基于存在或不存在CBI和EXE的四个子类别中患者的生存率差异显着（T1为P = .018; T2至T4为P <.001）。最大直径超过5毫米的EXE的预后要比较小的扩展差（P <.001），并且被分配为单独的子类别。 I，IIA至IIB和IIIA至IIIC的十年Kaplan-Meier生存估计分别为88％，80％，67％，45％，27％，10％（P <.001）。结论在美国癌症联合委员会第七版《癌症分期手册》中，这种基于证据的解剖学分类为睫状体和脉络膜黑色素瘤的分期提供了基础。

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