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首页> 外文期刊>Journal of chromatography, A: Including electrophoresis and other separation methods >Weak anion-exchange hypercrosslinked sorbent in on-line solid-phase extraction-liquid chromatography coupling to achieve automated determination with an effective clean-up
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Weak anion-exchange hypercrosslinked sorbent in on-line solid-phase extraction-liquid chromatography coupling to achieve automated determination with an effective clean-up

机译：在线固相萃取-液相色谱联用中弱阴离子交换超交联吸附剂，可实现自动测定并进行有效的净化

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摘要

A mixed-mode polymeric sorbent was on-line coupled to liquid chromatography (LC) for the first time and applied to the selective solid-phase extract a group of pharmaceuticals in complex environmental water samples. The mixed-mode polymeric sorbent is a high-specific surface area hypercrosslinked polymer resin (HXLPP) in the form of monodisperse microspheres further modified with 1,2-ethylenediamine (EDA) moieties. These properties allow its application as a weak anion-exchange (WAX) sorbent in the on-line solid-phase extraction (SPE) coupling. The on-line SPE-LC method developed using the HXLPP-WAX sorbent was successfully applied to percolate a large volume of ultrapure (500 ml), river (250 ml) and effluent sewage (100 ml) water samples. In all the cases, the HXLPP-WAX resin provided near total recoveries of the most acidic compounds studied and clean chromatograms. This is because the ion-exchange interactions enable a washing step to be added to the SPE protocol that removes the compounds with weak acidic, neutral and basic properties from the sample matrix.
机译：首次将混合模式聚合物吸附剂在线连接到液相色谱（LC），并将其应用于选择性固相提取物中复杂环境水样品中的一组药物。混合模式聚合物吸附剂是单分散微球形式的高比表面积超交联聚合物树脂（HXLPP），进一步用1,2-乙二胺（EDA）部分进行了改性。这些特性使其可以在在线固相萃取（SPE）偶联剂中用作弱阴离子交换（WAX）吸附剂。使用HXLPP-WAX吸附剂开发的在线SPE-LC方法已成功应用于大量超纯水（500 ml），河流（250 ml）和污水（100 ml）水样品的渗透。在所有情况下，HXLPP-WAX树脂都能提供所研究的最酸性化合物的总回收率和干净的色谱图。这是因为离子交换相互作用使得可以将洗涤步骤添加到SPE规程中，从而从样品基质中去除具有弱酸性，中性和碱性的化合物。

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