Complementary enantiorecognition patterns and specific method optimization aspects on immobilized polysaccharide-derived chiral stationary phases

Zhang T.; Franco P.; Nguyen D.; Hamasaki R.; Miyamoto S.; Ohnishi A.; Murakami T.

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Complementary enantiorecognition patterns and specific method optimization aspects on immobilized polysaccharide-derived chiral stationary phases

机译：固定化多糖衍生的手性固定相的互补对映体识别模式和具体方法优化方面

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摘要

The immobilized polysaccharide-derived chiral stationary phases (CSPs) combine the benefits of broad application scope and high preparative potential with CSP robustness and universal solvent compatibility. Strategies for efficient and straightforward method development with these CSPs were previously overviewed. In the current study, six CSPs with different structural features in the immobilized series were examined for their complementary properties in separation of enantiomers. Some method development aspects related to polysaccharide-derived CSPs in general and certain specific features observed on these immobilized supports, such as the effects of mobile phase, sample solvent and mobile phase additive on chiral separation, are also discussed.

机译：固定化多糖衍生的手性固定相（CSP）结合了广泛的应用范围和高制备潜力以及CSP耐用性和通用溶剂相容性的优点。先前概述了使用这些CSP进行高效，直接的方法开发的策略。在当前的研究中，检查了固定系列中具有不同结构特征的6种CSP在分离对映体中的互补性质。还讨论了一些与多糖衍生的CSP有关的方法开发方面，以及在这些固定化载体上观察到的某些特定特征，例如流动相，样品溶剂和流动相添加剂对手性分离的影响。

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《Journal of chromatography, A: Including electrophoresis and other separation methods》 |2012年第null期|共11页
作者
Zhang T.; Franco P.; Nguyen D.; Hamasaki R.; Miyamoto S.; Ohnishi A.; Murakami T.;
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正文语种 eng
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Additive effect; Complementary properties; Enantiomer resolution by HPLC; Immobilized polysaccharide-based chiral stationary phases; Mobile phase effect; Sample solvent effect;

机译：加性作用;互补性质;对映体的HPLC拆分;固定化多糖基手性固定相;流动相效应;样品溶剂效应;

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1. Complementary enantiorecognition patterns and specific method optimization aspects on immobilized polysaccharide-derived chiral stationary phases [J] . Zhang T., Franco P., Nguyen D., Journal of chromatography, A: Including electrophoresis and other separation methods . 2012,第Null期

机译：固定化多糖衍生的手性固定相的互补对映体识别模式和具体方法优化方面
2. Mechanistic considerations of enantiorecognition on novel Cinchona alkaloid-based zwitterionic chiral stationary phases from the aspect of the separation of trans-paroxetine enantiomers as model compounds [J] . Grecso Nora, Kohout Michal, Carotti Andrea, Journal of Pharmaceutical and Biomedical Analysis: An International Journal on All Drug-Related Topics in Pharmaceutical, Biomedical and Clinical Analysis . 2016,第Null期

机译：从反式帕罗西汀对映体作为模型化合物的分离方面，基于新型金鸡纳生物碱的两性离子手性固定相的对映体识别的机理考虑
3. Mechanistic considerations of enantiorecognition on novel Cinchona alkaloid-based zwitterionic chiral stationary phases from the aspect of the separation of trans-paroxetine enantiomers as model compounds [J] . Grecso Nora, Kohout Michal, Carotti Andrea, Journal of Pharmaceutical and Biomedical Analysis: An International Journal on All Drug-Related Topics in Pharmaceutical, Biomedical and Clinical Analysis . 2016,第Null期

机译：基于新型Cinchona生物碱的两性离子手性平静阶段的对嗜睡的机械考虑来自转毒氨基对映体分离作为模型化合物
4. Detection of Chiral Compound/Stationary Phase Interactions using Mass Spectrometry: A Rapid Screening Method for Chiral Stationary Phase Selection [C] . Melissa R. Thompson, James B. Murphy, David E. McKenzie American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2011

机译：使用质谱法检测手性化合物/固定相相互作用：一种手性静止相选择的快速筛选方法
5. Novel methods in chromatographic separations: New *chiral stationary phases and molecular tagging [D] . Blodgett, Jordan Danielle Haney 2004

机译：色谱分离的新方法：新的*手性固定相和分子标记
6. Comparison of Coated and Immobilized Chiral Stationary Phases Based on Amylose tris-( [O] . Alessia Rosetti, Claudio Villani, Marco Pierini, 2021

机译：基于直链淀粉的涂层和固定的手性固定阶段的比较 - （
7. Mechanistic considerations of enantiorecognition on novel Cinchona alkaloid-based zwitterionic chiral stationary phases from the aspect of the separation of trans-paroxetine enantiomers as model compounds [O] . Grecsó Nóra, Kohout Michal, Carotti Andrea, 2016

机译：从反式帕罗西汀对映体作为模型化合物的分离方面，基于新型金鸡纳生物碱的两性离子手性固定相的对映体识别的机理考虑

Complementary enantiorecognition patterns and specific method optimization aspects on immobilized polysaccharide-derived chiral stationary phases

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