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首页> 外文期刊>Current directions in psychological science: a journal of the American Psychological Society >Separation, Sickness, and Depression:A New Perspective on an Old Animal Model
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Separation, Sickness, and Depression:A New Perspective on an Old Animal Model

机译：分离，疾病和抑郁：旧动物模型的新观点

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摘要

Studies of prolonged separation from the at-tachment figure that were conducted with infant monkeysduring the middle of the 20th century identified a passivebehavioral response, termed "despair," that appeared tomodel human depressive illness. Studies in guinea pigs,which exhibit filial attachment that resembles attachmentin monkeys, have described a similar passive response tobriefer periods of maternal separation. Recent evidenceindicates that elements of the immune system mediate thepassive behavioral response of guinea pigs. These findingsaccord well with current ideas that immune responsescontribute to depressive illness, suggest new hypothesesabout how maternal separation might promote depression,and give us a rodent model in which such hypotheses mightbe tested.
机译：在20世纪中叶，对幼猴进行的长期分离与研究发现了一种被动的行为反应，称为“绝望”，似乎模仿了人类的抑郁症。对几内亚猪的研究显示出与猴子相似的孝子依恋，描述了对母系分离期的类似被动反应。最近的证据表明免疫系统的元素介导豚鼠的被动行为反应。这些发现与当前免疫应答会导致抑郁症的观点相吻合，提出了关于孕产妇分居如何促进抑郁症的新假设，并为我们提供了一种可以检验这种假设的啮齿动物模型。

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