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Recent advances in the histopathology of stromal tumours of the endometrium

机译:子宫内膜间质瘤组织病理学的最新进展

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Summary Stromal tumours of the endometrium can be difficult to distinguish from smooth muscle tumours of the uterus when evaluating conventional morphology alone. This review focuses on the value of immunohistochemical markers for diagnosing endometrial stromal tumours with emphasis on the recent literature. Low-grade endometrial stromal sarcomas show consistent expression of CD10 but the specificity of staining is low, since approximately 50% of highly cellular leiomyomas and almost all leiomyosarcomas are also positive for CD10. Therefore, a panel of markers must be used for distinguishing an endometrial stromal tumour from a uterine smooth muscle tumour, including antibodies against CD10, desmin, h-caldesmon and oxytocin receptors. On rare occasions, additional markers such as inhibin, CD117 and HMB-45 may be of help in the differential diagnosis.
机译:总结当单独评估常规形态时,子宫内膜间质瘤可能难以与子宫平滑肌瘤区分开。这篇综述着重于免疫组织化学标记物在诊断子宫内膜间质瘤中的价值,重点是最近的文献。低度子宫内膜间质肉瘤显示CD10的一致表达,但染色的特异性低,因为大约50%的高度细胞性平滑肌瘤和几乎所有平滑肌肉瘤也对CD10呈阳性。因此,必须使用一组标记物将子宫内膜间质瘤与子宫平滑肌肿瘤区分开,包括针对CD10,结蛋白,h-卡尔德斯蒙和催产素受体的抗体。在极少数情况下,其他标志物如抑制素,CD117和HMB-45可能有助于鉴别诊断。

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