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首页> 外文期刊>Current drug targets. CNS and neurological disorders >Cdk5 in the adult non-demented brain.
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Cdk5 in the adult non-demented brain.

机译：成人非痴呆脑中的cdk5。

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摘要

Cyclin-dependent kinase 5 (Cdk5), a Ser/Thr kinase, regulates the phosphorylation of neuronal proteins and thereby influences neuronal morphology, migration and axon growth. Tightly coordinated interactions between Cdk5 and its activator proteins p35 and p39 are critical for the developmental processes of post-mitotic neurons as well as functioning of the adult CNS. Excessive up-regulation of Cdk5 activity leading to hyperphosphorylation of cytoskeletal proteins has been linked to neurodegenerative disorders, such as Alzheimer's disease (AD). On this basis it was proposed that Cdk5 might be a promising drug target. The physiologic role of Cdk5 in the adult CNS has been addressed recently. It was demonstrated that Cdk5 is involved in striatal and hippocampal neuronal plasticity and long-term behavioral changes associated with these processes. On the basis of the newly identified role of Cdk5 in synaptic plasticity, learning and memory the view that Cdk5 represents a good drug target in AD accompanied bycognitive dysfunctions may have to be revisited. Alternatively, targeting the mechanisms up-stream of Cdk5 leading to deregulation of Cdk5 activity, such as proteolytic cleavage of its activating subunits may prove to be more beneficial as a therapeutical approach.
机译：细胞周期蛋白依赖性激酶5（Cdk5），一种Ser / Thr激酶，调节神经元蛋白的磷酸化，从而影响神经元的形态，迁移和轴突生长。 Cdk5及其激活蛋白p35和p39之间的紧密协调相互作用对于有丝分裂后神经元的发育过程以及成年中枢神经系统的功能至关重要。导致细胞骨架蛋白过度磷酸化的Cdk5活性过度上调与神经退行性疾病（例如阿尔茨海默氏病（AD））有关。在此基础上，有人提出Cdk5可能是有希望的药物靶标。 Cdk5在成人中枢神经系统中的生理作用最近已得到解决。结果表明，Cdk5参与了纹状体和海马神经元的可塑性和与这些过程相关的长期行为改变。根据新发现的Cdk5在突触可塑性中的作用，学习和记忆可能需要重新审视Cdk5代表AD伴有认知功能障碍的良好药物靶点的观点。备选地，靶向导致Cdk5活性失调的Cdk5上游机制，例如其活化亚基的蛋白水解切割，可能被证明作为治疗方法更有益。

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