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首页> 外文期刊>Current drug targets. CNS and neurological disorders >Biochemical and therapeutic effects of antioxidants in the treatment of Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis.
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Biochemical and therapeutic effects of antioxidants in the treatment of Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis.

机译：抗氧化剂在阿尔茨海默氏病，帕金森氏病和肌萎缩性侧索硬化症的治疗中具有生化和治疗作用。

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摘要

Aging is a major risk factor for neurodegenerative diseases including Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS). An unbalanced overproduction of reactive oxygen species (ROS) may give rise to oxidative stress which can induce neuronal damage, ultimately leading to neuronal death by apoptosis or necrosis. A large body of evidence indicates that oxidative stress is involved in the pathogenesis of AD, PD, and ALS. Several studies have shown that nutritional antioxidants (especially vitamin E and polyphenols) can block neuronal death in vitro, and may have therapeutic properties in animal models of neurodegenerative diseases including AD, PD, and ALS. Moreover, clinical data suggest that nutritional antioxidants might exert some protective effect against AD, PD, and ALS. In this paper, the biochemical mechanisms by which nutritional antioxidants can reduce or block neuronal death occurring in neurodegenerative disorders are reviewed. Particular emphasis will be given to the role played by the nuclear transcription factor -kB (NF-kB) in apoptosis, and in the pathogenesis of neurodegenerative disorders, such as AD, PD, and ALS. The effects of ROS and antioxidants on NF-kB function and their relevance in the pathophysiology of neurodegenerative diseases will also be examined.
机译：衰老是神经退行性疾病的主要危险因素，包括阿尔茨海默氏病（AD），帕金森氏病（PD）和肌萎缩性侧索硬化症（ALS）。活性氧（ROS）的不平衡过度生产可能会引起氧化应激，从而引起神经元损伤，最终导致神经元因凋亡或坏死而死亡。大量证据表明氧化应激与AD，PD和ALS的发病机理有关。多项研究表明，营养抗氧化剂（尤其是维生素E和多酚）可以在体外阻断神经元死亡，并且在包括AD，PD和ALS在内的神经退行性疾病动物模型中可能具有治疗作用。此外，临床数据表明，营养抗氧化剂可能对AD，PD和ALS发挥一定的保护作用。本文综述了营养抗氧化剂可以减少或阻断神经退行性疾病中发生的神经元死亡的生化机制。将特别强调核转录因子-kB（NF-kB）在细胞凋亡以及神经退行性疾病（例如AD，PD和ALS）的发病机理中的作用。还将研究ROS和抗氧化剂对NF-kB功能的影响及其在神经退行性疾病病理生理中的相关性。

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