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首页> 外文期刊>Journal of nanoscience and nanotechnology >Preparation and Characterization of Ethyl Cellulose-Based Core-Shell Microcapsules Containing Argy Wormwood Solution
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Preparation and Characterization of Ethyl Cellulose-Based Core-Shell Microcapsules Containing Argy Wormwood Solution

机译：含艾草液的乙基纤维素基核壳微胶囊的制备与表征

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摘要

Biodegradable ethyl cellulose (EC) based microcapsules for controlled delivery of Argy Wormwood solution (AWS) was prepared in this study by emulsion-solvent evaporation method using ethyl acetate as solvent. Effects of emulsifier, AWS concentration, EC concentration and ratios of core to shell on the size of the microcapsules, encapsulation efficiency (EE) and drug content were also examined in this study. The increase in the AWS or EC concentrations resulted in enlargement of the microcapsules'. The drug loading increased from 23% to 48% as the AWP concentration was changed from 2 wt% to 10 wt%, showing that capsules were insensitive to the EC content. The drug loading and EE increased with increasing core to shell ratio. Also, the ratio was 70: 30 when the drug loading and EE deceased. SEM images of microcapsules showed uniform spherical structures with smooth surfaces, with a particle size range distribution between 100 nm(-2).m. The Core-shell and hetero-structures were confirmed using optical micrograph. Release rate for the AWS from the microcapsules was up to 98% within 5 h with pH 2. Comparatively, the release rate for the AWS decreased significantly to 72% and 35%, with pH of 6 and 10 respectively, showing a sustained and prolonged release.
机译：本研究采用乳液-溶剂蒸发法，以乙酸乙酯为溶剂，制备了可控降解的Argy Wormwood溶液（AWS）可生物降解的乙基纤维素（EC）微囊。在本研究中，还研究了乳化剂，AWS浓度，EC浓度以及核壳比对微胶囊大小，包封效率（EE）和药物含量的影响。 AWS或EC浓度的增加导致微囊的增大。随着AWP浓度从2 wt％更改为10 wt％，载药量从23％增加到48％，表明胶囊对EC含量不敏感。随着核壳比的增加，载药量和EE增加。而且，当载药量和EE下降时，该比例为70:30。微胶囊的SEM图像显示出具有光滑表面的均匀球形结构，其粒径范围分布在100 nm（-2）.m之间。使用光学显微照片确认了核-壳和异质结构。在pH为2的情况下，AWS从微胶囊中释放的速率在5 h内高达98％。相比之下，在pH为6和10时，AWS的释放速率显着下降至72％和35％，显示了持续的和延长的释放。

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