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首页> 外文期刊>Journal of Molecular Biology >Allostery: Absence of a change in shape does not imply that allostery is not at play
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Allostery: Absence of a change in shape does not imply that allostery is not at play

机译：变构：没有形状变化并不表示变构没有发挥作用

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摘要

Allostery is essential for controlled catalysis, signal transmission, receptor trafficking, turning genes on and off, and apoptosis. It governs the organism's response to environmental and metabolic cues, dictating transient partner interactions in the cellular network. Textbooks taught us that allostery is a change of shape at one site on the protein surface brought about by ligand binding to another. For several years, it has been broadly accepted that the change of shape is not induced; rather, it is observed simply because a larger protein population presents it. Current data indicate that while side chains can reorient and rewire, allostery may not even involve a change of (backbone) shape. Assuming that the enthalpy change does not reverse the free-energy change due to the change in entropy, entropy is mainly responsible for binding.
机译：变构对于控制催化，信号传递，受体运输，打开和关闭基因以及凋亡均至关重要。它控制生物体对环境和代谢线索的反应，指示细胞网络中的短暂伴侣相互作用。教科书告诉我们，变构是蛋白质表面上一个位点的形状变化，是由配体与另一位点结合引起的。几年来，不引起形状变化已被广泛接受。而是仅仅因为存在大量蛋白质而被观察到。当前数据表明，尽管侧链可以重新定向和重新连接，但变构可能甚至不涉及（主干）形状的变化。假设由于熵的变化，焓的变化不会逆转自由能的变化，那么熵主要负责结合。

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