An alternative conformation of the T-cell receptor alpha constant region.

van Boxel GI; Holmes S; Fugger L; Jones EY

首页> 外文期刊>Journal of Molecular Biology >An alternative conformation of the T-cell receptor alpha constant region.

【24h】

An alternative conformation of the T-cell receptor alpha constant region.

机译：T细胞受体α恒定区的另一种构象。

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Alphabeta T-cell receptors (TcRs) play a central role in cellular immune response. They are members of the Ig superfamily, with extracellular regions of the alpha and beta chains each comprising a V-type domain and a C-type domain. We have determined the ectodomain structure of an alphabeta TcR, which recognizes the autoantigen myelin basic protein. The 2.0-A-resolution structure reveals canonical main-chain conformations for the V(alpha), V(beta), and C(beta) domains, but the C(alpha) domain exhibits a main-chain conformation remarkably different from those previously reported for TcR crystal structures. The global IgC-like fold is maintained, but a piston-like rearrangement between BC and DE beta-turns results in beta-strand slippage. This substantial conformational change may represent a signaling intermediate. Our structure is the first example for the Ig fold of the increasingly recognized concept of "metamorphic proteins."

机译：字母T细胞受体（TcRs）在细胞免疫反应中起着核心作用。它们是Ig超家族的成员，α和β链的胞外区域各包含一个V型结构域和一个C型结构域。我们已经确定了字母TcR的胞外域结构，该结构识别自身抗原髓鞘碱性蛋白。 2.0-A分辨率结构揭示了Vα，Vβ和Cβ域的规范主链构象，但Cα域显示的主链构象与以前的显着不同报道了TcR晶体结构。保持了整体的IgC样折叠，但BC和DE的β形转弯之间的活塞式重排导致β链滑动。这种基本的构象变化可以代表信号中间体。我们的结构是人们日益认可的“变形蛋白”概念的Ig折叠的第一个例子。

著录项

来源
《Journal of Molecular Biology》 |2010年第4期|共10页
作者
van Boxel GI; Holmes S; Fugger L; Jones EY;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类
关键词

相似文献

外文文献
中文文献
专利

1. An alternative conformation of the T-cell receptor alpha constant region. [J] . van Boxel GI, Holmes S, Fugger L, Journal of Molecular Biology . 2010,第4期

机译：T细胞受体α恒定区的另一种构象。
2. Inactivation of alpha7 ACh receptors and activation of non-alpha7 ACh receptors both contribute to long term potentiation induction in the hippocampal CA1 region. [J] . Fujii S, Ji Z, Sumikawa K Neuroscience Letters: An International Multidisciplinary Journal Devoted to the Rapid Publication of Basic Research in the Brain Sciences . 2000,第2期

机译：alpha7 ACh受体的失活和非alpha7 ACh受体的失活都有助于海马CA1区的长期增强。
3. Coexpression of the T-cell receptor constant alpha domain triggers tumor reactivity of single-chain TCR-transduced human T cells. [J] . Voss RH, Thomas S, Pfirschke C, Blood: The Journal of the American Society of Hematology . 2010,第25期

机译：T细胞受体恒定α结构域的共表达触发单链TCR转导的人T细胞的肿瘤反应性。
4. Receptor-bound conformation of alpha-peptide of transucin (G_t) is not stabilized by a "pi-cation" interaction but by constrained lactam bridges between residues 341 and 350 [C] . Wei Sha, Rieko Arimoto, Garland R.Marshall the International Peptide Symposium . 2001

机译：通过“Pi-Cataation”相互作用，不稳定α-肽（G_T）的α-肽的受体 - 结合构象，而是通过残留物341和350之间的约束的内酰胺桥稳定
5. Biophysical characterization of zinc(II)-binding domains in two systems: Neural zinc finger factor-1 and T-cell co-receptors DC4 and DC8 alpha with T-cell-specific kinase Lck. [D] . Davis, Alisa M. 2007

机译：锌（II）结合域在两个系统中的生物物理特征：神经锌指因子1和T细胞共受体DC4和DC8α与T细胞特异性激酶Lck。
6. An Alternative Conformation of the T-Cell Receptor α Constant Region [O] . Gijs I. van Boxel, Samantha Holmes, Lars Fugger, -1

机译：T细胞受体α恒定区的替代构型
7. An alternative conformation of the T-cell receptor alpha constant region. [O] . van Boxel, GI, Holmes, S, Fugger, L, 2010

机译：T细胞受体α恒定区的另一种构象。
8. Partial Primary Structure of the Alpha and Beta Chains of Human Tumor T-Cell Receptors [R] . Jones, N., Leiden, J., Dialynas, D., 1985

机译：人肿瘤T细胞受体α和β链的部分一级结构

An alternative conformation of the T-cell receptor alpha constant region.

摘要

著录项

相似文献

相关主题

期刊订阅