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A rare example of lock-and-key RNA recognition.

机译：锁匙RNA识别的罕见例子。

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Our view of how biomolecules bind one another and ligands has come a long way since Fischer first introduced the "lock-and-key" mechanism to explain how enzymes specifically bind their substrates more than a century ago. Biomolecules generally do not interact with their partners as rigid bodies; rather, their structures change adaptively to optimize inter-molecular interactions through "induced-fit" and "conformational selection" type mechanisms. Adaptive recognition is particularly common in flexible RNAs where conformational changes provide the basis for sensing, processing, and transmitting chemical information. With current efforts directed at understanding the mechanistic underpinnings of these conformational transitions, the lock-and-key mechanism seems like a relic of the past. On page 555, Dumey and D'Souza provide a rare example of lock-and-key RNA recognition. What makes these findings all the more interesting is that the HTV virus has evolved a structurally and functionally related RNA that binds the same ligand via a distinct conformational selection/induced-fit-type mechanism.
机译：自Fischer自一个多世纪以来首次提出“锁钥”机制来解释酶如何特异性结合其底物以来，我们对生物分子如何相互结合以及配体的观点已经走了很长一段路。生物分子通常不与它们的伴侣相互作用为刚性体。相反，它们的结构通过“诱导拟合”和“构象选择”类型的机制自适应地改变，以优化分子间的相互作用。自适应识别在柔性RNA中尤其常见，在柔性RNA中，构象变化为传感，处理和传输化学信息提供了基础。在当前旨在理解这些构象转变的机械基础的努力下，锁匙机制似乎已成为过去。在第555页，Dumey和D'Souza提供了一个罕见的锁钥RNA识别示例。使这些发现更加令人感兴趣的是，HIV病毒已经进化出结构和功能相关的RNA，该RNA通过独特的构象选择/诱导拟合类型机制结合相同的配体。

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