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Who initiates proteasomal degradation?

机译：谁引发蛋白酶体降解？

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摘要

Ubiquitin conjugation has emerged as a key player in the regulation of numerous cellular processes.1 It is best known for its fundamental role in the regulation of protein degradation.2 However, ubi-quitination of lysines on substrates and subsequent binding to the proteasome is not sufficient for effective degradation.3"5 A degradation initiation site has to be presented by the substrate to the proteasome. Intrinsically disordered (ID) regions can act as effective degradation initiation sites. In a seminal study, Prakash et al. have shown that ubiquitinated proteins in vitro are stable unless they contain an ID region.5 Functional ID initiation sites can be located at the protein's termini or internally but, in the latter case, must be much longer.
机译：泛素结合已成为调节许多细胞过程的关键因素。1最著名的是其在调节蛋白质降解中的基本作用。2然而，赖氨酸在底物上的泛素化以及随后与蛋白酶体的结合尚不明确。 3“ 5降解起始位点必须由底物提供给蛋白酶体。内在无序（ID）区域可以充当有效的降解起始位点。在一项开创性研究中，Prakash等人已证明泛素化除非它们包含一个ID区，否则体外蛋白质是稳定的。5功能性ID起始位点可以位于蛋白质的末端或内部，但在后者的情况下，必须更长。

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