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18S rRNA: a tale of the tail.

机译:18S rRNA:尾巴的故事。

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More than 40 years ago, the Nomura group seduced the ribosome community with the breath-takingly simple reconstitution of the E. coli 30S ribosomal subunit from its component RNA and proteins. However, as with many seductions, the morning-after reality is sobering. In actual fact, the complexity of ribosome synthesis and assembly is staggering, especially in eukaryotes, where some 200 proteins and 100 small RNA molecules are required to covalently modify the rRNA transcript, cleave it, trim it, fold it, and assemble it with the ribosomal proteins (reviewed in Refs. 2 and 3).
机译:40多年前,野村研究小组利用其成分RNA和蛋白质对大肠杆菌30S核糖体亚基进行了令人惊讶的简单重组,从而诱骗了核糖体社区。但是,就像许多诱惑一样,早起的现实令人清醒。实际上,核糖体合成和组装的复杂性令人震惊,尤其是在真核生物中,需要约200个蛋白质和100个小RNA分子共价修饰rRNA转录本,将其切割,修剪,折叠并与rRNA组装。核糖体蛋白(参见参考文献2和3)。

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