• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Molecular Biology >Structural and thermodynamic effects of post-translational modifications in mutant and wild type Cu, Zn superoxide dismutase.
【24h】

Structural and thermodynamic effects of post-translational modifications in mutant and wild type Cu, Zn superoxide dismutase.

机译：突变和野生型铜，锌超氧化物歧化酶翻译后修饰的结构和热力学效应。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Aggregation of Cu,Zn superoxide dismutase (SOD1) is implicated in amyotrophic lateral sclerosis. Glutathionylation and phosphorylation of SOD1 is omnipresent in the human body, even in healthy individuals, and has been shown to increase SOD1 dimer dissociation, which is the first step on the pathway toward SOD1 aggregation. We found that post-translational modification of SOD1, especially glutathionylation, promotes dimer dissociation. We discovered an intermediate state in the pathway to dissociation, a conformational change that involves a loosening interactions. In modified SOD1, this intermediate state is stabilized as compared to unmodified SOD1. The presence of post-translational modifications could explain the environmental factors involved in the speed of disease progression. Because post-translational modifications such as glutathionylation are often induced by oxidative stress, post-translational modification of SOD1 could be a factor in the occurrence of sporadic cases of amyotrophic lateral sclerosis, which represent 90% of all cases of the disease.
机译：Cu，Zn超氧化物歧化酶（SOD1）的聚集与肌萎缩性侧索硬化有关。 SOD1的谷胱甘肽化和磷酸化在人体中无处不在，即使在健康的个体中也已普遍存在，并且已证明可增加SOD1二聚体的解离，这是通往SOD1聚集途径的第一步。我们发现SOD1的翻译后修饰，尤其是谷胱甘肽酰化，可促进二聚体解离。我们在解离途径中发现了一种中间状态，这是一种结构变化，涉及到相互作用的松散。与未修饰的SOD1相比，在修饰的SOD1中，该中间状态得以稳定。翻译后修饰的存在可以解释与疾病进展速度有关的环境因素。由于翻译后修饰（例如谷胱甘肽酰化）通常是由氧化应激诱导的，因此SOD1的翻译后修饰可能是发生肌萎缩性侧索硬化的偶发病例的一个因素，占该病所有病例的90％。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号