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Chromatin-Driven Behavior of Topologically Associating Domains

机译:拓扑关联域的染色质驱动行为

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Metazoan genomes are highly organized inside the cell nucleus. Topologically associating domains (TADs) represent the building blocks of genome organization, but their linear modularity does not explain alone their spatial organization. Indeed, the chromatin type adorning a TAD can shape its structure and drives its nuclear positioning and its function. Genome-wide association studies revealed mainly four chromatin types: active chromatin, Polycomb-repressed chromatin, null chromatin and constitutive heterochromatin. In this review, we will describe the main three-dimensional features of each chromatin type and finally their relationships with TAD organization and epigenetic memory (c) 2014 The Authors. Published by Elsevier Ltd.
机译:后生动物的基因组在细胞核内高度组织。拓扑关联域(TAD)代表了基因组组织的基本组成部分,但其线性模块化并不能单独解释其空间组织。确实,装饰TAD的染色质类型可以改变其结构,并驱动其核定位和功能。全基因组关联研究主要揭示了四种染色质类型:活性染色质,Polycomb抑制染色质,无效染色质和组成型异染色质。在这篇综述中,我们将描述每种染色质的主要三维特征,以及它们与TAD组织和表观遗传记忆的关系(c)2014 The Authors。由Elsevier Ltd.发布

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