• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Molecular Biology >On the possible amyloid origin of protein folds
【24h】

On the possible amyloid origin of protein folds

机译：关于蛋白质折叠的淀粉样蛋白来源

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The diversity of protein folds is derived from the diversity of the underlying proteome. Such diversity must have originated from a so-called common ancestor: a hypothetical fold whose identity will, in all likelihood, never be known. Nonetheless, hypotheses exist to explain the evolution of protein folds. When formulating such hypotheses as done here, the entire repertoire of polypeptide structure, from well-defined tertiary structures and molten globule states to intrinsically disordered proteins and oligomeric aggregates, is worth considering. It is the aim of this short essay to discuss the hypothesis that one type of protein aggregate - the cross-β-sheet motif - was the first functional protein fold, that is, the common ancestor fold. Support for this hypothesis comes from the observations that (i) short peptides with simple amino acid sequences are able to form the cross-β-sheet structure, (ii) amyloids can be very stable under harsh conditions, (iii) amyloids can self-assemble in complex mixtures, (iv) amyloids have many potent activities that are attributable to the inherent repetitiveness of the structure, and (v) the proteomes of modern organisms appear to have evolved away from the more amyloidogenic sequences of older organisms, suggesting that amyloids were more ubiquitous earlier in the evolution of modern protein folds.
机译：蛋白质折叠的多样性源自基础蛋白质组的多样性。这种多样性一定源于所谓的共同祖先：一种假想的褶皱，其身份很可能永远不会被知道。然而，存在假说来解释蛋白质折叠的演变。当制定这种假设时，值得考虑的是多肽结构的全部组成部分，从定义明确的三级结构和熔融小球状态到内在无序的蛋白质和寡聚体。这篇简短文章的目的是讨论以下假设：一种蛋白质聚集体-交叉β-折叠基序-是第一个功能性蛋白质折叠，即共同的祖先折叠。该假设的支持来自以下观察结果：（i）具有简单氨基酸序列的短肽能够形成交叉的β-折叠结构，（ii）淀粉样蛋白在恶劣条件下可能非常稳定，（iii）淀粉样蛋白可以自我组装成复杂的混合物，（iv）淀粉样蛋白具有许多强大的活性，这归因于该结构的固有重复性，并且（v）现代生物的蛋白质组似乎已从较老的生物体的更多淀粉样蛋白形成序列进化而来，这表明淀粉样蛋白在现代蛋白质折叠的进化中更普遍。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号