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首页> 外文期刊>Journal of Molecular Biology >The tiers and dimensions of evasion of the type i interferon response by human cytomegalovirus
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The tiers and dimensions of evasion of the type i interferon response by human cytomegalovirus

机译：人类巨细胞病毒回避I型干扰素反应的层次和大小

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摘要

Human cytomegalovirus (HCMV) is a member of the β-herpesvirus family that invariably occupies hosts for life despite a consistent multi-pronged antiviral immune response that targets the infection. This persistence is enabled by the large viral genome that encodes factors conferring a wide assortment of sophisticated, often redundant phenotypes that disable or otherwise manipulate impactful immune effector processes. The type I interferon system represents a first line of host defense against infecting viruses. The physiological reactions induced by secreted interferon act to effectively block replication of a broad spectrum of virus types, including HCMV. As such, the virus must exhibit counteractive mechanisms to these responses that involve their inhibition, tolerance, or re-purposing. The goal of this review is to describe the impact of the type I interferon system on HCMV replication and to showcase the number and diversity of strategies employed by the virus that allow infection of hosts in the presence of interferon-dependent activity.
机译：人类巨细胞病毒（HCMV）是β疱疹病毒家族的一员，尽管针对感染的一致的多管抗病毒免疫反应却始终占据着宿主的生命。这种持久性是由大型病毒基因组实现的，该基因组编码赋予多种复杂的，常常是冗余的表型的因子，这些表型禁用或操纵有影响力的免疫效应子过程。 I型干扰素系统代表宿主抵抗感染病毒的第一道防线。分泌的干扰素诱导的生理反应可有效阻止包括HCMV在内的多种病毒复制。因此，病毒必须对这些反应表现出反作用机制，这些机制涉及其抑制，耐受或重新设定目的。这篇综述的目的是描述I型干扰素系统对HCMV复制的影响，并展示该病毒采用的策略的数量和多样性，这些策略允许在干扰素依赖性活性的存在下感染宿主。

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