首页> 外文期刊>Journal of Molecular Biology >A new toolkit for modeling RNA from a pseudo-torsional space: Commentary on 'discrete RNA libraries from pseudo-torsional space' by Humphris-Narayanan and Pyle (J. Mol. Biol. March 2012)
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A new toolkit for modeling RNA from a pseudo-torsional space: Commentary on 'discrete RNA libraries from pseudo-torsional space' by Humphris-Narayanan and Pyle (J. Mol. Biol. March 2012)

机译:一种用于模拟伪扭转空间中的RNA的新工具包:Humphris-Narayanan和Pyle对“伪扭转空间中的离散RNA库”的评论(J. Mol。Biol。2012年3月)

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摘要

RNA's diverse cellular roles from catalysis and molecular recognition to genetic regulation are highly dependent on its tertiary structure (see recent reviews in Refs. 1-3 and breakthrough papers in Refs. 4-8). Fortunately, the number of known RNA tertiary structures has greatly increased over the past 20 years through experimental studies. The emerging field of RNA computational biology has capitalized well upon this growing information to develop tools that model RNA tertiary structures (see recent reviews in Refs. 9 and 10). In turn, computational approaches have also contributed to annotating and analyzing RNA's modular and hierarchical features.
机译:从催化和分子识别到基因调控,RNA的多种细胞作用高度依赖于其三级结构(请参见参考文献1-3中的最新评论以及参考文献4-8中的突破性论文)。幸运的是,在过去的20年中,通过实验研究,已知的RNA三级结构的数量已大大增加。 RNA计算生物学的新兴领域已经充分利用了这些不断增长的信息来开发出可对RNA三级结构进行建模的工具(参见参考文献9和10中的最新评论)。反过来,计算方法也有助于注释和分析RNA的模块化和分层特征。

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