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首页> 外文期刊>Journal of Molecular Biology >Replication stress-induced genome instability: The dark side of replication maintenance by homologous recombination
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Replication stress-induced genome instability: The dark side of replication maintenance by homologous recombination

机译：复制应激诱导的基因组不稳定性：通过同源重组维持复制的黑暗面

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Homologous recombination (HR) is an evolutionary-conserved mechanism involved in a subtle balance between genome stability and diversity. HR is a faithful DNA repair pathway and has been largely characterized in the context of double-strand break (DSB) repair. Recently, multiple functions for the HR machinery have been identified at arrested forks. These are evident across different organisms and include replication fork-stabilization and fork-restart functions. Interestingly, a DSB appears not to be a prerequisite for HR-mediated replication maintenance. HR has the ability to rebuild a replisome at inactivated forks, but perhaps surprisingly, the resulting replisome is liable to intrastrand and interstrand switches leading to replication errors. Here, we review our current understanding of the replication maintenance function of HR. The error proneness of these pathways leads us to suggest that the origin of replication-associated genome instability should be re-evaluated.
机译：同源重组（HR）是一种进化保守的机制，涉及基因组稳定性和多样性之间的微妙平衡。 HR是一个忠实的DNA修复途径，在双链断裂（DSB）修复的背景下具有很大的特点。最近，在被逮捕的货叉上发现了人力资源机械的多种功能。这些在不同的生物体中很明显，包括复制叉稳定和叉重新启动功能。有趣的是，DSB似乎不是HR介导的复制维护的先决条件。 HR具有在灭活的分叉处重建复制子的能力，但也许令人惊讶的是，所得复制子易于在链内和链间切换，导致复制错误。在这里，我们回顾对HR复制维护功能的当前了解。这些途径的错误倾向使我们建议应该重新评估与复制相关的基因组不稳定性的起源。

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