The 1.8-? crystal structure of the N-terminal domain of an archaeal MCM as a right-handed filament.

Yang Fu; Ian M Slaymaker; Junfeng Wang; Ganggang Wang; Xiaojiang S Chen

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The 1.8-? crystal structure of the N-terminal domain of an archaeal MCM as a right-handed filament.

机译：1.8-？作为右手丝状的古细菌MCM N端结构域的晶体结构。

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Mini-chromosome maintenance (MCM) proteins are the replicative helicase necessary for DNA replication in both eukarya and archaea. Most of archaea only have one MCM gene. Here, we report a 1.8-? crystal structure of the N-terminal MCM from the archaeon Thermoplasma acidophilum (tapMCM). In the structure, the MCM N-terminus forms a right-handed filament that contains six subunits in each turn, with a diameter of 25? of the central channel opening. The inner surface is highly positively charged, indicating DNA binding. This filament structure with six subunits per turn may also suggests a potential role for an open-ring structure for hexameric MCM and dynamic conformational changes in initiation and elongation stages of DNA replication.

机译：微型染色体维持（MCM）蛋白是在真核生物和古细菌中进行DNA复制所必需的复制解旋酶。大多数古细菌只有一个MCM基因。在这里，我们报告1.8-？嗜碱古生菌嗜热菌（tapMCM）的N末端MCM的晶体结构。在结构中，MCM N端形成一个右手丝，每匝包含六个亚基，直径为25?。中央通道开口的角度。内表面带正电，表明DNA结合。每匝具有六个亚基的这种长丝结构也可能暗示了六聚体MCM的开环结构以及DNA复制起始和延伸阶段动态构象变化的潜在作用。

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《Journal of Molecular Biology》 |2014年第7期|共12页
作者
Yang Fu; Ian M Slaymaker; Junfeng Wang; Ganggang Wang; Xiaojiang S Chen;
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1. The 1.8-? crystal structure of the N-terminal domain of an archaeal MCM as a right-handed filament. [J] . Yang Fu, Ian M Slaymaker, Junfeng Wang, Journal of Molecular Biology . 2014,第7期

机译：1.8-？作为右手丝状的古细菌MCM N端结构域的晶体结构。
2. Crystallization of the two-domain N-terminal fragment of the archaeal ribosomal protein L10(P0) in complex with a specific fragment of 23S rRNA [J] . Kravchenko O.V., Mitroshin I.V., Gabdulkhakov A.G., Crystallography reports . 2011,第4期

机译：与23S rRNA的特定片段复杂的古细菌核糖体蛋白L10（P0）的两个域的N端片段的结晶。
3. Novel structure of an N-terminal domain that is crucial for the dimeric assembly and DNA-binding of an archaeal DNA polymerase D large subunit from Pyrococcus horikoshii. [J] . Matsui I, Urushibata Y, Shen Y, FEBS letters. . 2011,第3a4期

机译：N末端结构域的新结构，这对于来自火球菌的古细菌DNA聚合酶D大亚基的二聚体组装和DNA结合至关重要。
4. The Three-Dimensional Structure of the N-Terminal Domain of Corticotropin-Releasing Factor Receptors:Sushi Domains and the B1 Family of G Protein—Coupled Receptors [C] . MARILYN H. PERRIN, CHRISTY R. R. GRACE, ROLAND RIEK, International Symposium on VIP, PACAP, and Related Peptides . 2006

机译：皮质激素释放因子受体N-末端结构域的三维结构：寿司结构域和B1蛋白偶联受体的B1系列
5. Structure and function of archaeal MCM helicase. [D] . Brewster, Aaron Samuel. 2010

机译：古细菌MCM解旋酶的结构和功能。
6. Crystal structure of the CD2-binding domain of CD58 (lymphocyte function-associated antigen 3) at 1.8-Å resolution [O] . Shinji Ikemizu, Lisa M. Sparks, P. Anton van der Merwe, 1999

机译：CD58的CD2结合结构域（淋巴细胞功能相关抗原3）的晶体结构分辨率为1.8-Å
7. The Crystal Structure of the Plexin-Semaphorin-Integrin Domain/Hybrid Domain/I-EGF1 Segment from the Human Integrin β2 Subunit at 1.8-Å Resolution [O] . MinLong Shi, Kumar Sundramurthy, Bin Liu, 2005

机译：Plexin-Semaphorin-整合素结构域/杂种结构域/ I-EGF1在1.8-Å分辨率下的人整合蛋白β2亚基晶体结构

The 1.8-? crystal structure of the N-terminal domain of an archaeal MCM as a right-handed filament.

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