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首页> 外文期刊>Current drug targets. CNS and neurological disorders >A perspective on the current strategies for the treatment of obesity.
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A perspective on the current strategies for the treatment of obesity.

机译：对目前肥胖治疗策略的看法。

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The prevalence in obesity has increased dramatically over the past 30 years, more than double in the United States alone. Obesity is associated with an increased risk for type 2 diabetes mellitus, dyslipidemia, hypertension, biliary disease, obstructive sleep apnea, and certain types of cancer. The pathophysiology of obesity is complex, involving behavioral, environmental, and genetic factors. Current treatment options include behavior modification and lifestyle changes which incorporate weight-reducing diets and physical activity, FDA approved long-term anti-obesity pharmacological agents sibutramine and orlistat, non-FDA approved over-the-counter (OTC) supplements and nutriceuticals, and, when appropriate, bariatric surgery. Without adequate prevention and treatment of obesity, government agencies have suggested that the direct and indirect costs associated with obesity may overwhelm the healthcare system. This brief review explores the current data available on treatments for the obese patient including the relative merits of different types of macronutrient composition (e.g., low carbohydrate vs. high carbohydrate diets) of weight-reducing diets, the value of resistance/ strength training in physical activity programs designed for the obese patient, the safety and efficacy associated with OTC supplements and nutriceuticals for weight reduction (e.g., Ephedra, conjugated linoleic acid (CLA), Garcinia cambogia/ hydroxycitric acid (HCA), chromium, pyruvate), the safety and efficacy of FDA-approved long-term obesity treatments sibutramine and orlistat, and bariatric surgery.
机译：在过去的30年中，肥胖症的患病率急剧上升，仅在美国就超过两倍。肥胖与2型糖尿病，血脂异常，高血压，胆道疾病，阻塞性睡眠呼吸暂停和某些类型的癌症的风险增加相关。肥胖症的病理生理学很复杂，涉及行为，环境和遗传因素。当前的治疗选择包括行为改变和生活方式改变，其中包括降低体重的饮食和体育锻炼; FDA批准的长期抗肥胖药理药物西布曲明和奥利司他;非FDA批准的非处方药（OTC）补充剂和营养保健品;以及适当时进行减肥手术。如果没有对肥胖症进行充分的预防和治疗，政府机构建议，与肥胖症相关的直接和间接费用可能会使医疗体系不堪重负。这篇简短的综述探讨了有关肥胖患者治疗的当前可用数据，包括减肥饮食中不同类型的大量营养素成分（例如，低碳水化合物与高碳水化合物饮食）的相对优点，身体抵抗力/力量训练的价值专为肥胖患者设计的活动计划，与OTC补充剂和减肥药相关的安全性和有效性（例如麻黄，共轭亚油酸（CLA），藤黄果/羟基柠檬酸（HCA），铬，丙酮酸），安全性和FDA批准的长期肥胖疗法西布曲明和奥利司他以及减肥手术的疗效。

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