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首页> 外文期刊>Current drug targets. CNS and neurological disorders >Methods for providing therapeutic agents to treat damaged spiral ganglion neurons.
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Methods for providing therapeutic agents to treat damaged spiral ganglion neurons.

机译：提供用于治疗受损螺旋神经节神经元的治疗剂的方法。

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摘要

Sensorineural hearing loss, characterized by damage to sensory hair cells and/or associated nerve fibers is a leading cause of hearing disorders throughout the world. To date, treatment options are limited and there is no cure for damaged inner ear cells. Because the inner ear is a tiny organ housed in bone deep within the skull, access to the inner ear is limited, making delivery of therapeutic agents difficult. In recent years scientists have investigated a number of growth factors that have the potential to regulate survival or recovery of auditory neurons. Coinciding with the focus on molecules that may restore function are efforts to develop novel delivery methods. Researchers have been investigating the use of mini osmotic pumps, viral vectors and stem cells as a means of providing direct application of growth factors to the inner ear. This review summarizes recent findings regarding the molecules that may be useful for restoring damaged spiral ganglion neurons, as well as the advantages and disadvantages of various delivery systems.
机译：以感觉性毛细胞和/或相关神经纤维受损为特征的感觉神经性听力损失是全世界听力障碍的主要原因。迄今为止，治疗选择是有限的，并且无法治愈受损的内耳细胞。由于内耳是颅骨深处骨骼中所容纳的微小器官，因此进入内耳的通道受到限制，从而难以输送治疗剂。近年来，科学家研究了许多可能调节听觉神经元存活或恢复的生长因子。与对可能恢复功能的分子的关注相一致的是，人们正在努力开发新颖的递送方法。研究人员一直在研究使用微型渗透泵，病毒载体和干细胞作为直接向内耳提供生长因子的手段。这篇综述总结了有关可用于恢复受损螺旋神经节神经元的分子的最新发现，以及各种输送系统的优缺点。

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