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首页> 外文期刊>Current drug targets. CNS and neurological disorders >Voltage-gated sodium channels & pain.
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Voltage-gated sodium channels & pain.

机译：电压门控钠通道和疼痛。

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摘要

Voltage-gated sodium channels are highly specialized molecular transducers that play a significant role in the creation and transmission of electrical activity throughout the neuraxis. These ion channels are fundamentally involved in sensory neuron physiology and pathophysiology; a complete but localized suspension of their normal function can prevent all sensation - including that perceived as pain. Soft-tissue injuries that result in inflammation or direct damage to nerve fibers have each been shown to result in abnormal sodium channel function and, in many cases, to lead to pathological hyperexcitability in the sensory afferent nerves that innervate the injured dermatome or visceral organ. Abrogating abnormal activity whilst leaving normal sensation unaffected would represent a powerful approach to pain relief. This article reviews the evidence supporting abnormal sodium channel biology in various pathological contexts, the opportunities that this presents for novel therapeutics and progress towardsrealizing this goal.
机译：电压门控钠通道是高度专业化的分子传感器，在整个神经轴的电活动的产生和传递中起着重要作用。这些离子通道从根本上参与感觉神经元生理和病理生理。完全但局部地停止其正常功能可以防止所有感觉，包括感觉到的疼痛。导致炎症或直接损伤神经纤维的软组织损伤均被证明会导致钠通道功能异常，并且在许多情况下，会导致感觉传入神经的病理性过度兴奋，从而使受伤的皮肤刀或内脏器官支配。放弃异常活动，同时保持正常感觉不受影响将代表一种有效的缓解疼痛的方法。本文回顾了在各种病理情况下支持异常钠通道生物学的证据，这为新型疗法提供了机会，并为实现这一目标取得了进展。

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