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首页> 外文期刊>Current drug targets. CNS and neurological disorders >Neuronal plasticity, stress and depression: involvement of the cytoskeletal microtubular system?
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Neuronal plasticity, stress and depression: involvement of the cytoskeletal microtubular system?

机译：神经元可塑性，压力和抑郁：细胞骨架微管系统受累了吗？

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In susceptible individuals, stressors can increase the risk of onset of depression and recent brain imaging studies have shown morphometric alterations in the limbic system of patients affected by depression. The volume loss observed in the hippocampus of depressed individuals suggests a possible involvement of structural neuronal plasticity in the pathogenesis of depression. Stressful conditions in animals can result in impaired structural neuronal plasticity in the hippocampus, characterised by retraction of apical dendrites and decreased neurogenesis. The intrinsic dynamic instability of the cytoskeletal microtubular system is essential for neuronal remodelling and plasticity. We have recently shown that both acute and chronic stress decrease microtubular dynamics in the rat hippocampus. Other authors have demonstrated that proteins functionally involved in the regulation of microtubule dynamics can be altered by stress in the rodent hippocampus. Furthermore, the existence of a link between stress-induced microtubular changes and depression is further strengthened by evidence showing that both acute and chronic treatment with antidepressant drugs can affect the expression of microtubular proteins. The present review will introduce a growing body of evidence suggesting that stress-induced alterations in neuronal plasticity might be considered the final result of activation and/or inhibition of molecular cascades regulating the dynamics of the microtubular system. In addition, the prospect of targeting microtubules as a pharmacotherapeutic approach to treat mood disorders will be discussed.
机译：在易感人群中，压力源会增加患抑郁症的风险，最近的脑成像研究表明，患有抑郁症的患者的边缘系统形态发生了改变。在抑郁的个体的海马体中观察到的体积损失表明，抑郁症的发病机制可能涉及结构神经元可塑性。动物的压力条件可能导致海马结构神经元可塑性受损，其特征是根尖树突缩回和神经发生减少。细胞骨架微管系统固有的动态不稳定性对于神经元重塑和可塑性至关重要。我们最近显示，急性和慢性应激都会降低大鼠海马中的微管动力学。其他作者已经证明，啮齿类海马体中的应激可以改变功能上参与微管动力学调节的蛋白质。此外，有证据表明，抗抑郁药的急性和慢性治疗均可影响微管蛋白的表达，从而进一步增强了应力引起的微管变化与抑郁之间的联系。本综述将引入越来越多的证据，表明应力诱导的神经元可塑性改变可能被认为是调节和/或抑制调节微管系统动力学的分子级联反应的最终结果。另外，将讨论靶向微管作为治疗情绪障碍的药物治疗方法的前景。

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