The Evolutionary Persistence of Genes That Increase Mental Disorders Risk

Keller MC

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The Evolutionary Persistence of Genes That Increase Mental Disorders Risk

机译：增加精神障碍风险的基因的进化持久性

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Natural selection constantly removes those genetic variants (alleles) that even slightly decrease average reproductive success. Yet, given the high heritabilities and prevalence rates of severe mental disorders, human populations seem to be awash in deleterious alleles. Evolutionary genetics offers an illuminating framework for understanding why mental disorder risk alleles have persisted despite natural selection, and this framework can help guide future research in behavioral and psychiatric genetics.

机译：自然选择会不断去除那些甚至会稍微降低平均繁殖成功率的遗传变异（等位基因）。然而，鉴于严重的精神障碍的高遗传力和患病率，人类似乎充满了有害的等位基因。进化遗传学提供了一个有启发性的框架，用于理解为什么尽管自然选择，精神疾病风险等位基因仍会持续存在，并且该框架可以帮助指导行为和精神病学遗传学的未来研究。

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《Current directions in psychological science: a journal of the American Psychological Society》 |2008年第6期|共5页
作者
Keller MC;
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正文语种 eng
中图分类心理学;
关键词
mental disorders; genetics; evolution; mutation-selection; balancing selection; schizophrenia; HUMAN GENOME; COMMON; SCHIZOPHRENIA; SELECTION; MODEL;

机译：精神疾病;遗传学;进化;突变选择;平衡选择;精神分裂症;人类基因组;常见;精神分裂症;选择;模型;

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1. The Evolutionary Persistence of Genes That Increase Mental Disorders Risk [J] . Keller MC Current directions in psychological science: a journal of the American Psychological Society . 2008,第6期

机译：增加精神障碍风险的基因的进化持久性
2. Persistence or recurrence of non-psychotic comorbid mental disorders associated with 6-year poor functional outcomes in patients at ultra high risk for psychosis [J] . Rutigliano Grazia, Valmaggia Lucia, Landi Paola, Journal of affective disorders . 2016,第Null期

机译：非精神病性合并症的持续性或复发性与精神病超高风险患者的6年不良功能结局相关
3. Communication and behavioural disorders among children with hearing loss increases risk of mental health disorders [J] . Anthony Hogan, Megan Shipley, Lyndall Strazdins, Australian and New Zealand Journal of Public Health . 2011,第4期

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7. The evolutionary persistence of genes that increase mental disorders risk [O] . Matthew C. Keller 2015

机译：增加精神障碍的基因的进化持续存在风险

The Evolutionary Persistence of Genes That Increase Mental Disorders Risk

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