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首页> 外文期刊>Journal of Non-Crystalline Solids: A Journal Devoted to Oxide, Halide, Chalcogenide and Metallic Glasses, Amorphous Semiconductors, Non-Crystalline Films, Glass-Ceramics and Glassy Composites >Neutron scattering perspectives for protein dynamics
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Neutron scattering perspectives for protein dynamics

机译：中子散射观点对蛋白质动力学的影响

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摘要

After a double decade of intensive neutron scattering studies of the biological physics of protein dynamics on a few well-characterised model systems, the time has come to extend the method to address the vast biological diversity of proteins and their dynamics-function relationships. The time-scale and length-scale dependent mean square displacement and effective force constant, measured by neutron elastic intensity temperature scans, are proposed as relevant experimental parameters, and examples are given of their correlation with biological function. The parameters are directly calculable from molecular dynamics simulations, and their proposed deposit in an accessible data bank will greatly strengthen the links between experimental and theoretical approaches to protein dynamics.
机译：在几十个特征明确的模型系统上对蛋白质动力学的生物物理学进行了长达十年的深入中子散射研究之后，现在该扩展该方法以解决蛋白质的巨大生物多样性及其动力学与功能关系的时候了。提出了通过中子弹性强度温度扫描测量的与时标和时标相关的均方位移和有效力常数作为相关实验参数，并举例说明了它们与生物学功能的关系。这些参数可直接从分子动力学模拟计算得出，并将它们建议的存放在可访问的数据库中，将大大加强蛋白质动力学的实验方法和理论方法之间的联系。

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