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首页> 外文期刊>Journal of Non-Crystalline Solids: A Journal Devoted to Oxide, Halide, Chalcogenide and Metallic Glasses, Amorphous Semiconductors, Non-Crystalline Films, Glass-Ceramics and Glassy Composites >Development and characterization of lithium-releasing silicate bioactive glasses and their scaffolds for bone repair
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Development and characterization of lithium-releasing silicate bioactive glasses and their scaffolds for bone repair

机译：释锂硅酸盐生物活性玻璃及其骨修复支架的研制与表征

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Incorporation of therapeutic ions into the structure of bioactive glasses for direct stimulation of cells is a very attractive approach for tissue engineering strategies. Lithium has recently been identified as a biologically active ion which can stimulate osteoblast cell activity. In this study, lithium-containing bioactive glasses (Li-BGs) where Li2O substitutes Na2O in different amounts (2.5, 5 and 10 wt.% Li2O) in 45S5 bioactive glass (BC) were produced and made into 3D scaffolds by the foam replica method. The structural changes that occur after heat treatment, the effect of lithium-content on the bioactivity of the glasses and their lithium ion release profiles were investigated. The results show that the novel Li-BC formulations exhibit the formation of an apatite-like layer on their surface after immersion in SBF for 1 day thus confirming their high surface reactivity, similar to undoped 45S5 BC. XRD results showed that the Li-doped BGs crystallize mainly to combeite (Na2Ca2Si3O9) and silicorhenanite (SiO4(PO4)(2)Ca-5) but also Li6P6O18 and Li3PO4 phases were detected. In terms of lithium ion release, the formulations at 2.5 wt.% and 5 wt.% Li2O content were the only ones to be within the therapeutic range (<83 ppm). (C) 2015 Elsevier B.V. All rights reserved.
机译：对于组织工程策略来说，将治疗离子掺入生物活性玻璃的结构中以直接刺激细胞是一种非常有吸引力的方法。锂最近被鉴定为一种生物活性离子，可以刺激成骨细胞活性。在这项研究中，生产了含锂的生物活性玻璃（Li-BG），其中Li2O替代了45S5生物活性玻璃（BC）中不同量（2.5、5和10重量％Li2O）的Na2O，并通过泡沫复制品制成3D支架。方法。研究了热处理后发生的结构变化，锂含量对玻璃生物活性的影响及其锂离子释放曲线。结果表明，新型Li-BC配方在SBF中浸泡1天后在其表面上形成了磷灰石样层，从而证实了其高表面反应性，类似于未掺杂的45S5 BC。 XRD结果表明，掺锂的BG主要结晶为方铅矿（Na2Ca2Si3O9）和硅锰矿（SiO4（PO4）（2）Ca-5），但也检测到Li6P6O18和Li3PO4相。就锂离子释放而言，Li 2 O含量为2.5重量％和5重量％的制剂是唯一在治疗范围内（＜83ppm）的制剂。 （C）2015 Elsevier B.V.保留所有权利。

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