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首页> 外文期刊>Journal of Non-Crystalline Solids: A Journal Devoted to Oxide, Halide, Chalcogenide and Metallic Glasses, Amorphous Semiconductors, Non-Crystalline Films, Glass-Ceramics and Glassy Composites >An injectable borate bioactive glass cement for bone repair: Preparation, bioactivity and setting mechanism
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An injectable borate bioactive glass cement for bone repair: Preparation, bioactivity and setting mechanism

机译：用于骨骼修复的可注射硼酸盐生物活性玻璃胶泥：制备，生物活性和固化机制

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摘要

There is a need for synthetic biomaterials to reconstruct bone defects using minimal invasive surgery. In this study, the preparation, bioactivity and setting mechanism of an injectable cement composed of borate bioactive glass particles and a chitosan solution was evaluated as a function of varying solid to liquid (SL) ratio. As the SL ratio increased from 1.0 g/ml to 2.5 g/ml, the injectability and initial setting time decreased from 97 +/- 1% to 84 +/- 10% and from 16.9 +/- 0.9 min to 3.0 +/- 0.5 min, respectively, while the compressive strength of the cement increased from 8 +/- 2 MPa to 31 +/- 2 MPa. The cement maintained its cohesiveness in a vigorously stirred aqueous medium. When immersed in phosphate-buffered saline, the glass phase reacted and converted to hydroxyapatite. The setting mechanism of the cement appeared to involve a combination of processes, such as the sol-gel transition of the chitosan solution, formation of an interlocked interface between the converted glass surface and the chitosan, and bonding between the converted glass surface and the functional groups of the chitosan. By controlling the reaction between the glass particles and the chitosan solution, injectable cements can be created with the requisite workability, degradation, strength and bioactivity for bone repair applications. (C) 2015 Elsevier B.V. All rights reserved.
机译：需要使用微创手术来重建骨缺损的合成生物材料。在这项研究中，评估了由硼酸盐生物活性玻璃颗粒和壳聚糖溶液组成的可注射水泥的制备，生物活性和固化机理，作为固液比变化的函数。当SL比从1.0 g / ml增加到2.5 g / ml时，可注射性和初始凝固时间从97 +/- 1％降低到84 +/- 10％，从16.9 +/- 0.9分钟降低到3.0 +/-分别为0.5分钟，而水泥的抗压强度从8 +/- 2 MPa增加到31 +/- 2 MPa。水泥在剧烈搅拌的水性介质中保持其内聚性。当浸入磷酸盐缓冲盐水中时，玻璃相反应并转化为羟基磷灰石。水泥的固化机理似乎涉及多种过程的组合，例如壳聚糖溶液的溶胶-凝胶转变，转化玻璃表面与壳聚糖之间形成互锁界面，以及转化玻璃表面与功能玻璃之间的键合。壳聚糖。通过控制玻璃颗粒和壳聚糖溶液之间的反应，可以生产出具有骨修复应用所需的可加工性，降解性，强度和生物活性的可注射水泥。 （C）2015 Elsevier B.V.保留所有权利。

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