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首页> 外文期刊>Journal of Neurophysiology >Response properties from turtle auditory hair cell afferent fibers suggest spike generation is driven by synchronized release both between and within synapses
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Response properties from turtle auditory hair cell afferent fibers suggest spike generation is driven by synchronized release both between and within synapses

机译：乌龟听觉毛细胞传入纤维的响应特性表明，突触之间和之内的同步释放驱动了突峰的产生

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Inner ear hair cell afferent fiber synapses are capable of transferring information at high rates for long periods of time with extraordinary fidelity. As at other sensory synapses, hair cells rely on graded receptor potentials and unique vesicle trafficking and release properties of ribbon synapses to relay intensity information. Postsynaptic recordings from afferent fibers of the turtle auditory papilla identified excitatory postsynaptic currents (EPSCs) that were fast AMPA receptor-based responses with rapid onset and decay times. EPSCs varied in amplitude by ~15× per fiber, with kinetics that showed a tendency to slow at larger amplitudes. Complex EPSCs were produced by temporal summation of single events, likely across synapses. Complex EPSCs were more efficient at generating action potentials than single EPSCs. Potassium-evoked release increased the frequency of EPSCs, in particular complex events, but did not increase EPSC amplitudes. Temporal summation of EPSCs across synapses may underlie action potential generation at these synapses. Broad amplitude histograms were probed for mechanisms of multivesicular release with reduced external Ca2+ or the introduction of Cd2+ or Sr2+ to uncouple release. The results are consistent with broad amplitude histograms being generated by a combination of the variability in synaptic vesicle size and coordinated release of these vesicles. It is posited that multivesicular release plays less of a role in multisynaptic ribbon synapses than in single synaptic afferent fibers.
机译：内耳毛细胞传入纤维突触能够以极高的保真度以高速率长时间传输信息。与其他感觉突触一样，毛细胞依赖于分级的受体电位和独特的囊泡运输，以及带状突触的释放特性来传递强度信息。乌龟听觉乳头传入纤维的突触后记录确定了兴奋性突触后电流（EPSC），这些电流是基于AMPA受体的快速反应，起效和衰减时间短。每根光纤的EPSC振幅变化约15倍，动力学表现出在较大振幅下趋于减慢的趋势。复杂的EPSC通过单个事件的时间求和产生，可能跨越突触。复杂的EPSC在产生动作电位方面比单个EPSC更有效。钾引起的释放增加了EPSC的频率，特别是在复杂事件中，但没有增加EPSC的幅度。跨突触的EPSC的时间总和可能是这些突触产生动作电位的基础。探查宽幅振幅直方图，以了解减少外部Ca2 +或引入Cd2 +或Sr2 +解除偶联的多囊泡释放机制。该结果与通过突触小泡大小的可变性和这些小泡的协同释放所产生的宽幅直方图一致。假定多囊泡释放在多突触带状突触中的作用比在单突触传入纤维中少。

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