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首页> 外文期刊>Journal of Neurophysiology >Ketamine disrupts theta synchrony across the septotemporal axis of the CA1 region of hippocampus
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Ketamine disrupts theta synchrony across the septotemporal axis of the CA1 region of hippocampus

机译：氯胺酮破坏海马CA1区隔颞轴的theta同步

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The hippocampal theta signal reflects moment-to-moment variation in the synchrony of synaptic input to hippocampal neurons. Consistent with the topography of hippocampal afferents, the synchrony (coherence) of the theta signal varies across the septotemporal axis. Septotemporal variation in the theta signal can also be observed in relation to ongoing and past experience. Thus there is a systematic decrease in the relationship between locomotor speed and theta power across the septotemporal axis, septal hippocampus exhibiting the strongest relationship. Conversely, theta in temporal hippocampus decrements over repeated behavioral experience (running episodes), while theta in the septal hippocampus does not. Ketamine is an iV-methyl-D-aspartate (NMDA) antagonist that can decrease theta power. The present study examined whether ketamine treatment could alter theta coherence across the long axis independent of changes in locomotor behavior. Rats were well trained to navigate a linear runway and outfitted with electrodes at different septotemporal positions within CA1. Locomotor behavior and theta coherence and power were examined after administration of 2.5 and 10 mg/kg ketamine. Ketamine (2.5 mg/kg) decreased theta coherence between distant CA1 electrode sites without altering running speed or theta power. Both doses of ketamine also blunted and reversed the decrement in theta power observed at midseptotemporal and temporal electrodes over repeated run sessions. The results demonstrate the sensitivity of global network synchronization to relatively low doses of ketamine and septotemporal differences in the influence of ketamine on hippocampal dynamics in relation to past experience.
机译：海马theta信号反映了海马神经元突触输入同步中的瞬间变化。与海马传入的地形一致，theta信号的同步性（相干性）在隔颞轴上变化。相对于进行中的和过去的经验，θ信号的时空变化也可以观察到。因此，跨隔颞轴的运动速度与theta功率之间的关系有系统地降低，其中间隔海马表现出最强的关系。相反，颞海马的theta会随着重复的行为经验（连续发作）而减少，而隔海马的theta不会。氯胺酮是一种iV-甲基-D-天冬氨酸（NMDA）拮抗剂，可以降低theta功效。本研究检查了氯胺酮治疗是否可以改变长轴的θ相干性，而与运动行为的变化无关。对大鼠进行良好的训练以使其在线性跑道上穿行，并在CA1内不同时间隔位置配备电极。服用2.5和10 mg / kg氯胺酮后，检查运动行为，θ相干性和功率。氯胺酮（2.5 mg / kg）降低了远处CA1电极位点之间的theta相干性，而没有改变运行速度或theta功率。两次剂量的氯胺酮也使钝化和逆转在重复运行过程中在中颞颞和颞电极观察到的theta功率下降。结果表明，全球网络同步对于相对较低剂量的氯胺酮的敏感性以及氯胺酮对海马动力学的影响的时空差异与过去的经验有关。

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