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首页> 外文期刊>Journal of Neurophysiology >Rhythmic activity of feline dorsal and ventral spinocerebellar tract neurons during fictive motor actions
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Rhythmic activity of feline dorsal and ventral spinocerebellar tract neurons during fictive motor actions

机译：虚构运动过程中猫背和腹脊髓小脑束神经元的节律活动

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摘要

Neurons of the dorsal spinocerebellar tracts (DSCT) have been described to be rhythmically active during walking on a treadmill in decerebrate cats, but this activity ceased following deafferentation of the hindlimb. This observation supported the hypothesis that DSCT neurons primarily relay the activity of hindlimb afferents during locomotion, but lack input from the spinal central pattern generator. The ventral spinocerebellar tract (VSCT) neurons, on the other hand, were found to be active during actual locomotion (on a treadmill) even after deafferentation, as well as during fictive locomotion (without phasic afferent feedback). In this study, we compared the activity of DSCT and VSCT neurons during fictive rhythmic motor behaviors. We used decerebrate cat preparations in which fictive motor tasks can be evoked while the animal is paralyzed and there is no rhythmic sensory input from hindlimb nerves. Spinocerebellar tract cells with cell bodies located in the lumbar segments were identified by electrophysiological techniques and examined by extra- and intracellular microelectrode recordings. During fictive locomotion, 57/81 DSCT and 30/30 VSCT neurons showed phasic, cycle-related activity. During fictive scratch, 19/29 DSCT neurons showed activity related to the scratch cycle. We provide evidence for the first time that locomotor and scratch drive potentials are present not only in VSCT, but also in the majority of DSCT neurons. These results demonstrate that both spinocerebellar tracts receive input from the central pattern generator circuitry, often sufficient to elicit firing in the absence of sensory input.
机译：在小脑猫的跑步机上行走时，脊髓小脑背侧神经元（DSCT）的神经节律性活跃，但后肢脱咖啡因后，该神经元活动停止了。该观察结果支持以下假设：DSCT神经元在运动过程中主要中继后肢传入的活动，但缺乏来自脊柱中央模式生成器的输入。另一方面，发现腹侧脊髓小脑束（VSCT）神经元在实际运动过程中（在跑步机上）即使在脱除力后也处于活动状态，并且在虚构运动过程中（没有阶段传入反馈）也处于活动状态。在这项研究中，我们比较了虚构的节律性运动行为期间DSCT和VSCT神经元的活动。我们使用了去脑猫制剂，其中在动物瘫痪时可以引发虚构的运动任务，并且没有后肢神经的节律性感觉输入。通过电生理技术鉴定出位于腰椎节段中的具小体的脊髓小脑束细胞，并通过细胞外和细胞内微电极记录进行检查。在虚拟运动期间，57/81 DSCT和30/30 VSCT神经元显示出与周期相关的阶段性活动。在虚拟刮擦过程中，19/29 DSCT神经元显示出与刮擦周期有关的活动。我们首次提供证据，不仅在VSCT中，而且在大多数DSCT神经元中都存在运动和划痕驱动电位。这些结果表明，两个脊髓小脑束都从中央模式发生器电路接收输入，通常足以在没有感觉输入的情况下引发放电。

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