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首页> 外文期刊>Journal of Neurophysiology >Two interconnected kernels of reciprocally inhibitory interneurons underlie alternating left-right swim motor pattern generation in the mollusk Melibe leonina
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Two interconnected kernels of reciprocally inhibitory interneurons underlie alternating left-right swim motor pattern generation in the mollusk Melibe leonina

机译：互为抑制的中间神经元的两个相互连接的内核在软体动物Melibe leonina中交替产生左右游泳运动模式

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摘要

The central pattern generator (CPG) un derlying the rhythmic swimming behavior of the nudibranch Melibe leonina (Mollusca, Gastropoda, Heterobranchia) has been described as a simple half-center oscillator consisting of two reciprocally inhibitory pairs of interneurons called swim interneuron 1 (Si1) and swim interneuron 2 (Si2). In this study, we identified two additional pairs of interneurons that are part of the swim CPG: swim interneuron 3 (Si3) and swim interneuron 4 (Si4). The somata of Si3 and Si4 were both located in the pedal ganglion, near that of Si2, and both had axons that projected through the pedal commissure to the contralateral pedal ganglion. These neurons fulfilled the criteria for inclusion as members of the swim CPG: 1) they fired at a fixed phase in relation to Si1 and Si2, 2) brief changes in their activity reset the motor pattern, 3) prolonged changes in their activity altered the periodicity of the motor pattern, 4) they had monosynaptic connections with each other and with Si1 and Si2, and 5) their synaptic actions helped explain the phasing of the motor pattern. The results of this study show that the motor pattern has more complex internal dynamics than a simple left/right alternation of firing; the CPG circuit appears to be composed of two kernels of reciprocally inhibitory neurons, one consisting of Si1, Si2, and the contralateral Si4 and the other consisting of Si3. These two kernels interact with each other to produce a stable rhythmic motor pattern.
机译：中央模式生成器（CPG）是裸露的梅利伯·莱昂尼娜（软体动物，腹足纲动物，异性支气管）节律性游泳行为的基础，已被描述为一个简单的半中心振荡器，由两个相互抑制的中间神经元对组成，称为游泳中间神经元1（Si1）。并游动interneuron 2（Si2）。在这项研究中，我们确定了游泳CPG的另外两对中间神经元：游泳中间神经元3（Si3）和游泳中间神经元4（Si4）。 Si3和Si4的躯体都位于踏板神经节中，靠近Si2，并且都具有通过踏板接合处投射到对侧踏板神经节的轴突。这些神经元符合列入游泳CPG成员的标准：1）他们以与Si1和Si2有关的固定相位激发，2）短暂的活动改变会重置运动模式，3）长时间的活动改变会改变运动模式运动模式的周期性; 4）它们彼此之间以及与Si1和Si2具有单突触连接，以及5）它们的突触作用有助于解释运动模式的定相。这项研究的结果表明，与简单的左右点火交替相比，电动机模式具有更复杂的内部动力学。 CPG回路似乎由两个相互抑制的神经元核组成，一个由Si1，Si2和对侧Si4组成，另一个由Si3组成。这两个内核相互交互以产生稳定的节奏运动模式。

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