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首页> 外文期刊>Journal of Neurophysiology >Taste coding in the parabrachial nucleus of the pons in awake, freely licking rats and comparison with the nucleus of the solitary tract
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Taste coding in the parabrachial nucleus of the pons in awake, freely licking rats and comparison with the nucleus of the solitary tract

机译：清醒，自由舔食大鼠脑桥臂旁核中的味觉编码，并与孤立道核进行比较

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摘要

In the rodent, the parabrachial nucleus of the pons (PbN) receives information about taste directly from the nucleus of the solitary tract (NTS). Here we examined how information about taste quality (sweet, sour, salty, and bitter) is conveyed in the PbN of awake, freely licking rats, with a focus on how this information is transformed from the incoming NTS signals. Awake rats with electrodes in the PbN had free access to a lick spout that delivered taste stimuli (5 consecutive licks; 100 mM NaCl, 10 mM citric acid, 0.01 mM quinine HO, or 100 mM sucrose and water) or water (as a rinse) on a variable-ratio schedule. To assess temporal coding, a family of metrics that quantifies the similarity of two spike trains in terms of spike count and spike timing was used. PbN neurons in = 49) were generally broadly tuned across taste qualities with variable response latencies. Some PbN neurons were quiescent during lick bouts, and others, some taste responsive, showed time-locked firing to the lick pattern. Compared with NTS neurons, spike timing played a larger role in signaling taste in the first 2 s of the response, contributing significantly in 78% (38/49) of PbN cells compared with 45% of NTS cells. Also, information from temporal coding increased at a faster rate as the response unfolded over time in PbN compared with NTS. Collectively, these data suggest that taste-related information from NTS converges in the PbN to enable a subset of PbN cells to carry a larger information load.
机译：在啮齿动物中，脑桥臂旁旁核（PbN）直接从孤立道（NTS）的核中接收有关味觉的信息。在这里，我们研究了如何在清醒，自由舔食大鼠的PbN中传达有关味觉质量（甜，酸，咸和苦）的信息，重点是如何从传入的NTS信号中转换此信息。处于PbN中且电极处于清醒状态的大鼠可以自由接触提供刺激味觉的舔嘴（连续5次舔; 100 mM NaCl，10 mM柠檬酸，0.01 mM奎宁HO或100 mM蔗糖和水）或水（冲洗） ）的可变比率计划。为了评估时间编码，使用了一系列指标，这些指标根据尖峰计数和尖峰时序量化了两个尖峰序列的相似性。在= 49）中的PbN神经元通常通过不同的反应潜伏期在口味品质上进行了广泛的调整。一些PbN神经元在舔b回合时处于静止状态，而其他一些对味觉有反应的则表现出对舔pattern方式的定时锁定。与NTS神经元相比，尖峰时间在反应的前2 s中在发觉味觉方面发挥更大的作用，与45％的NTS细胞相比，在78％（38/49）的PbN细胞中起重要作用。而且，与NTS相比，PbN中响应随时间的推移展开，来自时间编码的信息以更快的速度增加。总体而言，这些数据表明，来自NTS的与味觉相关的信息在PbN中收敛，从而使PbN细胞的子集能够承载更大的信息负荷。

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