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首页> 外文期刊>Journal of Neurophysiology >Anodal transcranial direct current stimulation of the motor cortex induces opposite modulation of reciprocal inhibition in wrist extensor and flexor
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Anodal transcranial direct current stimulation of the motor cortex induces opposite modulation of reciprocal inhibition in wrist extensor and flexor

机译：阳极经颅直流电刺激运动皮层在腕部伸肌和屈肌中引起相互抑制的相反调节

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Transcranial direct current stimulation (tDCS) is used as a noninvasive tool to modulate brain excitability in humans. Recently, several studies have demonstrated that tDCS applied over the motor cortex also modulates spinal neural network excitability and therefore can be used to explore the corticospinal control acting on spinal neurons. Previously, we showed that reciprocal inhibition directed to wrist flexor motoneurons is enhanced during contralateral anodal tDCS, but it is likely that the corticospinal control acting on spinal networks controlling wrist flexors and extensors is not similar. The primary aim of the study was to explore the effects of anodal tDCS on reciprocal inhibition directed to wrist extensor motoneurons. To further examine the supraspinal control acting on the reciprocal inhibition between wrist flexors and extensors, we also explored the effects of the tDCS applied to the ipsilateral hand motor area. In healthy volunteers, we tested the effects induced by sham and anodal tDCS on reciprocal inhibition pathways innervating wrist muscles. Reciprocal inhibition directed from flexor to extensor muscles and the reverse situation, i.e., reciprocal inhibition, directed from extensors to flexors were studied in parallel with the H reflex technique. Our main finding was that contralateral anodal tDCS induces opposing effects on reciprocal inhibition: it decreases reciprocal inhibition directed from flexors to extensors, but it increases reciprocal inhibition directed from extensors to flexors. The functional result of these opposite effects on reciprocal inhibition seems to favor wrist extension excitability, suggesting an asymmetric descending control onto the interneurons that mediate reciprocal inhibition.
机译：经颅直流电刺激（tDCS）用作调节人脑兴奋性的非侵入性工具。最近，一些研究表明，tDCS应用于运动皮层还可以调节脊髓神经网络的兴奋性，因此可以用于探索作用于脊髓神经元的皮质脊髓控制。先前，我们显示了在对侧肛门tDCS期间增强了对腕屈肌神经元的相互抑制作用，但是皮质脊髓控制作用于控制腕屈肌和伸肌的脊柱网络的可能性可能不相同。这项研究的主要目的是探讨阳极tDCS对针对腕伸运动神经元的相互抑制的影响。为了进一步检查腕上屈肌和伸肌之间相互抑制作用的脊髓上控制，我们还探讨了tDCS应用于同侧手运​​动区域的作用。在健康志愿者中，我们测试了假手术和阳极tDCS对支配腕部肌肉的相互抑制途径的诱导作用。与H反射技术并行研究了从屈肌到伸肌的相互抑制和相反的情况，即从伸肌到屈肌的相互抑制。我们的主要发现是对侧阳极tDCS对相互抑制产生相反的影响：它减少了从屈肌到伸肌的相互抑制，但增加了从伸肌到屈肌的相互抑制。这些对相互抑制的相反作用的功能结果似乎有利于腕部伸展的兴奋性，表明介导相互抑制的中间神经元的不对称下降控制。

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