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首页> 外文期刊>Journal of Neurophysiology >Disrupting information coding via block of 4-AP-sensitive potassium channels
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Disrupting information coding via block of 4-AP-sensitive potassium channels

机译：通过阻止4-AP敏感的钾离子通道破坏信息编码

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Recent interest has emerged on the role of intrinsic biophysical diversity in neuronal coding. An important question in neurophysiology is understanding which voltage-gated ion channels are responsible for this diversity and how variable expression or activity of one class of ion channels across neurons of a single type affects they way populations carry information. In mitral cells in the olfactory bulb of mice, we found that biophysical diversity was conferred in part by 4-amino-pyridine (4-AP)-sensitive potassium channels and reduced following block of those channels. When populations of mitral cells were stimulated with identical inputs, the diversity exhibited in their output spike patterns reduced with the addition of 4-AP, decreasing the stimulus information carried by ensembles of 15 neurons from 437 ?15 to 397 ?19 bits/s. Decreases in information were due to reduction in the diversity of population spike patterns generated in response to different features of the stimulus, suggesting that the coding capacity of a population can be altered by changes in the function of single ion channel types.
机译：对内在生物物理多样性在神经元编码中的作用的最新兴趣已经出现。神经生理学中的一个重要问题是了解哪些电压门控离子通道负责这种多样性，以及跨单一类型神经元的一类离子通道的可变表达或活性如何影响它们携带信息的方式。在小鼠嗅球的二尖瓣细胞中，我们发现生物物理多样性部分地由4-氨基吡啶（4-AP）敏感的钾通道赋予，并在阻断这些通道后减少。当二尖瓣细胞群受到相同的输入刺激时，其输出尖峰模式所表现出的多样性会因添加4-AP而降低，从而使15个神经元的整体所携带的刺激信息从437〜15降低至397〜19 bit / s。信息的减少是由于响应刺激的不同特征而产生的种群尖峰模式的多样性减少，这表明种群的编码能力可以通过改变单个离子通道类型的功能来改变。

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