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首页> 外文期刊>Journal of Neurophysiology >Linear summation in the barn owl's brainstem underlies responses to interaural time differences
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Linear summation in the barn owl's brainstem underlies responses to interaural time differences

机译：仓n脑干的线性求和是对耳间时间差的响应的基础

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摘要

The neurophonic potential is a synchronized frequency-following extracellular field potential that can be recorded in the nucleus laminaris (NL) in the brainstem of the barn owl. Putative generators of the neurophonic are the afferent axons from the nucleus magnocellularis, synapses onto NL neurons, and spikes of NL neurons. The outputs of NL, i.e., action potentials of NL neurons, are only weakly represented in the neurophonic. Instead, the inputs to NL, i.e., afferent axons and their synaptic potentials, are the predominant origin of the neurophonic (Kuokkanen PT, Wagner H, Ashida G, Carr CE, Kempter R. J Neurophysiol 104: 2274-2290, 2010). Thus in NL the monaural inputs from the two brain sides converge and create a binaural neurophonic. If these monaural inputs contribute independently to the extracellular field, the response to binaural stimulation can be predicted from the sum of the responses to ipsi- and contralateral stimulation. We found that a linear summation model explains the dependence of the responses on interaural time difference as measured experimentally with binaural stimulation. The fit between model predictions and data was excellent, even without taking into account the nonlinear responses of NL coincidence detector neurons, although their firing rate and synchrony strongly depend on the interaural time difference. These results are consistent with the view that the afferent axons and their synaptic potentials in NL are the primary origin of the neurophonic.
机译：神经电势是跟随频率的同步胞外场电势，可以记录在仓脑干的椎板核（NL）中。推定的神经发声源是来自巨细胞核的传入轴突，突触到NL神经元上，以及NL神经元的尖峰。 NL的输出，即NL神经元的动作电位，在神经语音中仅能较弱地表示。取而代之的是，NL的输入，即传入轴突及其突触电位是神经声学的主要起源（Kuokkanen PT，Wagner H，Ashida G，Carr CE，Kempter R.J Neurophysiol 104：2274-2290，2010）。因此，在NL中，来自大脑两个侧面的单声道输入会聚并产生双耳神经语音。如果这些单声道输入独立地贡献于细胞外场，则可以从对同侧和对侧刺激的响应之和预测对双耳刺激的响应。我们发现线性求和模型解释了双耳刺激实验测量的响应对耳间时间差的依赖性。即使不考虑NL重合检测器神经元的非线性响应，模型预测和数据之间的拟合度也非常好，尽管它们的触发频率和同步性很大程度上取决于耳间时间差。这些结果与以下观点一致：NL中传入的轴突及其突触电位是神经语音的主要来源。

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