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首页> 外文期刊>Journal of Neurophysiology >Serotonin modulates the excitatory synaptic transmission in the dentate granule cells
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Serotonin modulates the excitatory synaptic transmission in the dentate granule cells

机译：5-羟色胺调节齿状颗粒细胞中的兴奋性突触传递。

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摘要

Serotonergic fibers from the raphe nuclei project to the hippocampal formation, the activity of which is known to modulate the inhibitory interneurons in the dentate gyrus. On the other hand, serotonergic modulation of the excitatory synapses in the dentate gyrus is not well examined. In the present study, we examined the effects of 5-HT on the excitatory postsynaptic potentials (EPSPs) in the dentate granule cells evoked by the selective stimulation of the lateral perforant path (LPP), the medial perforant path (MPP), or the mossy cell fibers (MCF). 5-HT depressed the amplitude of unitary EPSPs (uEPSPs) evoked by the stimulation of LPP or MPP, whereas uEPSPs evoked by MCF stimulation were little affected. The effect was partly explained by the decrease of the resting membrane resistance following the activation of 5-HT 1A receptors, which was confirmed by computer simulations. We also found that the probability of evoking uEPSP by LPP stimulation but not MPP or MCF stimulation was reduced by 5-HT and that the paired-pulse ratio of LPP-evoked EPSP but not that of MPP-or MCF-evoked ones was increased by 5-HT. These effects were blocked by 5-HT 2 antagonist, suggesting that the transmitter release in the LPP-granule cell synapse is inhibited by the activation of 5-HT 2 receptors. The present results suggest that 5-HT can modulate the EPSPs in the dentate granule cells by at least two distinct mechanisms
机译：来自缝核的血清素能纤维投射到海马结构，已知其活性可调节齿状回中的抑制性中间神经元。另一方面，未充分检查齿状回中兴奋性突触的血清素能调节。在本研究中，我们研究了5-HT对通过选择性刺激外侧穿孔路径（LPP），内侧穿孔路径（MPP）或通过选择性刺激引起的齿状颗粒细胞兴奋性突触后电位（EPSPs）的影响。苔藓细胞纤维（MCF）。 5-HT抑制了LPP或MPP刺激引起的单一EPSPs（uEPSPs）的幅度，而MCF刺激引起的uEPSPs受到的影响很小。这种作用的部分原因是5-HT 1A受体激活后静息膜抗性降低，这可以通过计算机模拟得到证实。我们还发现，5-HT降低了通过LPP刺激而不是MPP或MCF刺激诱发uEPSP的可能性，并且LPP诱发的EPSP而不是MPP或MCF诱发的uPSP的配对脉冲比增加了。 5-羟色胺。这些作用被5-HT 2拮抗剂阻断，表明5-HT 2受体的激活抑制了LPP-颗粒细胞突触中的递质释放。目前的结果表明5-HT可以通过至少两种不同的机制调节齿状颗粒细胞中的EPSP

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